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Table 3 Intra-individual variability in docetaxel pharmacokinetic parameters in patients treated with 20 mg/m2 and 100 mg/m2

From: Pharmacokinetic analysis of two different docetaxel dose levels in patients with non-small cell lung cancer treated with docetaxel as monotherapy or with concurrent radiotherapy

 

Ratio cycle 2/cycle 1#

Variables

20 mg/m2

100 mg/m2

 

Median

Range

Median

Range

Cmax

1.06

0.4–1.6

1.07

0.9–1.3

AUC0–25

1.12

0.6–1.5

1.13

0.9–1.5

AUC0–72

1.12

0.8–1.3

ND

ND

Clearance

0.90

0.8–1.7

0.89

0.8–1.1

t1/2α

0.94

0.4–1.1

1.15

1.1–1.5

t1/2β

0.95

0.7–1.5

1.15

0.7–1.4

t1/2γ

1.03

0.7–1.3

ND

ND

C72h

0.92

0.6–2.1

ND

ND

AAG

0.98

0.7–1.7

1.15

0.9–1.4

  1. #: Each variable was calculated based on data from 4 to 10 patients.