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Table 3 Intra-individual variability in docetaxel pharmacokinetic parameters in patients treated with 20 mg/m2 and 100 mg/m2

From: Pharmacokinetic analysis of two different docetaxel dose levels in patients with non-small cell lung cancer treated with docetaxel as monotherapy or with concurrent radiotherapy

  Ratio cycle 2/cycle 1#
Variables 20 mg/m2 100 mg/m2
  Median Range Median Range
Cmax 1.06 0.4–1.6 1.07 0.9–1.3
AUC0–25 1.12 0.6–1.5 1.13 0.9–1.5
AUC0–72 1.12 0.8–1.3 ND ND
Clearance 0.90 0.8–1.7 0.89 0.8–1.1
t1/2α 0.94 0.4–1.1 1.15 1.1–1.5
t1/2β 0.95 0.7–1.5 1.15 0.7–1.4
t1/2γ 1.03 0.7–1.3 ND ND
C72h 0.92 0.6–2.1 ND ND
AAG 0.98 0.7–1.7 1.15 0.9–1.4
  1. #: Each variable was calculated based on data from 4 to 10 patients.