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Table 2 Docetaxel pharmacokinetic parameters in patients treated with 20 mg/m2 and 100 mg/m2

From: Pharmacokinetic analysis of two different docetaxel dose levels in patients with non-small cell lung cancer treated with docetaxel as monotherapy or with concurrent radiotherapy

  All cycles*
Variables 20 mg/m2 100 mg/m2
  Median Range Median Range
Cmax [nM] 742 389–1294 3737 2616–6949
AUC0–25 [nMh] 1284 848–1812 5562 3653–12790
AUC0–72 [nMh] 1541 996–2038 ND ND
Clearance [L/h/m2] 19.3 14–29 22.3 10–34
t1/2α [h] 0.99 0.8–2.0 0.74 0.5–1.0
t1/2β [h] 12.9 9–35 18.0 9–52
t1/2γ [h] 27.7 14–146 ND ND
C72h [nM] 3.0 0.7–6.5 ND ND
AAG [g/L] 1.6 0.7–2.7 1.5 0.8–2.9
  1. *: Each variable was calculated based on 11 to 27 cycles.