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Table 2 Docetaxel pharmacokinetic parameters in patients treated with 20 mg/m2 and 100 mg/m2

From: Pharmacokinetic analysis of two different docetaxel dose levels in patients with non-small cell lung cancer treated with docetaxel as monotherapy or with concurrent radiotherapy

 

All cycles*

Variables

20 mg/m2

100 mg/m2

 

Median

Range

Median

Range

Cmax [nM]

742

389–1294

3737

2616–6949

AUC0–25 [nMh]

1284

848–1812

5562

3653–12790

AUC0–72 [nMh]

1541

996–2038

ND

ND

Clearance [L/h/m2]

19.3

14–29

22.3

10–34

t1/2α [h]

0.99

0.8–2.0

0.74

0.5–1.0

t1/2β [h]

12.9

9–35

18.0

9–52

t1/2γ [h]

27.7

14–146

ND

ND

C72h [nM]

3.0

0.7–6.5

ND

ND

AAG [g/L]

1.6

0.7–2.7

1.5

0.8–2.9

  1. *: Each variable was calculated based on 11 to 27 cycles.
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BMC Cancer

ISSN: 1471-2407

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