Expression of NDRG2 is down-regulated in high-risk adenomas and colorectal carcinoma

BMC Cancer

Table 3 Mean values of normalised levels of NDRG2 mRNA in normal and affected colonic tissues.

	mRNA level in normal tissue Mean (SD)	p^a	mRNA level in adenomas/carcinomas Mean (SD)	p^a	p^b
Control	0.034 (0.009)
Low-risk Adenoma	0.044 (0.014)	NS	0.0407 (0.017)	NS	NS
High-risk Adenoma	0.041 (0.012)	NS	0.0307 (0.011)	NS	< 0.001
Carcinoma Normal (distant)	0.027 (0.015)	NS	0.0136 (0.012)	< 0.001	< 0.001 ^c
Carcinoma Normal (adjacent)	0.034 (0.021)	NS			< 0.001 ^d

NS = not significant.
^a p value when expression levels were compared to the control group of healthy individuals using one-way ANOVA with a Tukey's post test.
^b p value for comparison of mRNA expression levels in normal and tumor samples from the same individual using a paired two-tailed T-test.
^c p value when normal (distant) and corresponding tumor sample were compared.
^d p value when normal (adjacent) and corresponding tumor sample were compared.

ISSN: 1471-2407