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Table 2 Effect of doranidazole and anticancer agents on the cell killing of Colo 201 cell exposed to 30 Gy irradiation under hypoxia

From: The radiosensitizing effect of doranidazole on human colorectal cancer cells exposed to high doses of irradiation

Drugs

Dead cells (%)

 

No-irradiation

30 Gy irradiation

Control

0.2 ± 0.3

18.4 ± 3.4

Doranidazole (5 μM)

0.8 ± 6.3

35.8 ± 4.4 *

VP-16 (5 μM)

24.4 ± 1.7

36.9 ± 1.2 *

Cisplatin (10 μM)

27.1 ± 0.3

38.1 ± 3.5 *

SN-38 (10 μM)

21.2 ± 6.7

37.4 ± 9.1 *

5-FU (50 μM)

31.5 ± 1.8

47.6 ± 2.7 *

  1. * P < 0.01, compared with 30 Gy group
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BMC Cancer

ISSN: 1471-2407

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