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Table 2 Effect of doranidazole and anticancer agents on the cell killing of Colo 201 cell exposed to 30 Gy irradiation under hypoxia

From: The radiosensitizing effect of doranidazole on human colorectal cancer cells exposed to high doses of irradiation

Drugs Dead cells (%)
  No-irradiation 30 Gy irradiation
Control 0.2 ± 0.3 18.4 ± 3.4
Doranidazole (5 μM) 0.8 ± 6.3 35.8 ± 4.4 *
VP-16 (5 μM) 24.4 ± 1.7 36.9 ± 1.2 *
Cisplatin (10 μM) 27.1 ± 0.3 38.1 ± 3.5 *
SN-38 (10 μM) 21.2 ± 6.7 37.4 ± 9.1 *
5-FU (50 μM) 31.5 ± 1.8 47.6 ± 2.7 *
  1. * P < 0.01, compared with 30 Gy group