Skip to main content

Table 8 Mapping various gene signatures to core pathways

From: Pathway analysis of gene signatures predicting metastasis of node-negative primary breast cancer

   Published gene signaturesa
Pathways GO_ID Wang Van 't Veer Paik Yu Sotiriou
ER-positive tumors       
   Apoptosis 6915 X X X X X
   Regulation of cell cycle 74 X X X X X
   Protein amino acid phosphorylation 6468 X X X X X
   Cytokinesis 910 X X X   X
   Cell motility 6928     X X
   Cell cycle 7049 X X X X X
   Cell surface receptor-linked signal transd. 7166    X   
   Mitosis 7067 X X X X X
   Intracellular protein transport 6886 X X    X
   Mitotic chromosome segregation 70 X X    X
   Ubiquitin-dependent protein catabolism 6511   X   X X
   DNA repair 6281 X X   X X
   Induction of apoptosis 6917 X     
   Immune response 6955 X    X X
   Protein biosynthesis 6412    X X X
   DNA replication 6260 X X   X X
   Oncogenesis 7048    X X X
   Metabolism 8152 X X    
   Cellular defense response 6968 X    X X
   Chemotaxis 6935     X X
ER-negative tumors       
   Regulation of cell growth 1558   X    
   Regul. of G-coupled receptor signaling 8277      
   Skeletal development 1501 X X    
   Protein amino acid phosphorylation 6468 X X X X X
   Cell adhesion 7155 X X   X X
   Carbohydrate metabolism 5975 X X    
   Nuclear mRNA splicing, via spliceosome 398      
   Signal transduction 7165 X X X X  
   Cation transport 6812      
   Calciumion transport 6816      
   Protein modification 6464      
   Intracellular signaling cascade 7242 X X   X X
   mRNA processing 6397      
   RNA splicing 8380      
   Endocytosis 6897      
   Regul. of transcription from PolII promoter 6357     X  
   Regulation of cell cycle 74 X X X   
   Protein complex assembly 6461   X   X  
   Protein biosynthesis 6412    X   X
   Cell cycle 7049 X X X X X
  1. aPublished gene signatures that were studied include the 76-gene signature [8], the 70-gene signature [3], the 16-gene signature [25], the 62-gene signature [26], and the 97-gene signature [23]. Individual genes in each signature were mapped to the top 20 core pathways for ER-positive and ER-negative tumors, a cross indicates a match.