Table 1 Genes with highest frequencies in 500 signatures
From: Pathway analysis of gene signatures predicting metastasis of node-negative primary breast cancer
Gene title | Gene symbol | Frequency |
|---|---|---|
Top 20 core genes from ER-positive tumors | Â | Â |
   KIAA0241 protein | KIAA0241 | 321 |
   CD44 antigen (homing function and Indian blood group system) | CD44 | 286 |
   ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | ABCC5 | 251 |
   serine/threonine kinase 6 | STK6 | 245 |
   cytochrome c, somatic | CYCS | 235 |
   KIAA0406 gene product | KIA0406 | 212 |
   uridine-cytidine kinase 1-like 1 | UCKL1 | 201 |
   zinc finger, CCHC domain containing 8 | ZCCHC8 | 188 |
   Rac GTPase activating protein 1 | RACGAP1 | 186 |
   staufen, RNA binding protein (Drosophila) | STAU | 176 |
   lactamase, beta 2 | LACTB2 | 175 |
   eukaryotic translation elongation factor 1 alpha 2 | EEF1A2 | 172 |
   RAE1 RNA export 1 homolog (S. pombe) | RAE1 | 153 |
   tuftelin 1 | TUFT1 | 150 |
   zinc finger protein 36, C3H type-like 2 | ZFP36L2 | 150 |
   origin recognition complex, subunit 6 homolog-like (yeast) | ORC6L | 143 |
   zinc finger protein 623 | ZNF623 | 140 |
   extra spindle poles like 1 | ESPL1 | 139 |
   transcription elongation factor B (SIII), polypeptide 1 | TCEB1 | 138 |
   ribosomal protein S6 kinase, 70 kDa, polypeptide 1 | RPS6KB1 | 127 |
Top 20 core genes from ER-negative tumors | Â | Â |
   zinc finger protein, multitype 2 | ZFPM2 | 445 |
   ribosomal protein L26-like 1 | RPL26L1 | 372 |
   hypothetical protein FLJ14346 | FLJ14346 | 372 |
   mitogen-activated protein kinase-activated protein kinase 2 | MAPKAPK2 | 347 |
   collagen, type II, alpha 1 | COL2A1 | 340 |
   muscleblind-like 2 (Drosophila) | MBNL2 | 320 |
   G protein-coupled receptor 124 | GPR124 | 314 |
   splicing factor, arginine/serine-rich 11 | SFRS11 | 300 |
   heterogeneous nuclear ribonucleoprotein A1 | HNRPA1 | 297 |
   CDC42 binding protein kinase alpha (DMPK-like) | CDC42BPA | 296 |
   regulator of G-protein signalling 4 | RGS4 | 276 |
   transient receptor potential cation channel, subfamily C, member 1 | TRPC1 | 265 |
   transcription factor 8 (represses interleukin 2 expression) | TCF8 | 263 |
   chromosome 6 open reading frame 210 | C6orf210 | 262 |
   dynamin 3 | DNM3 | 260 |
   centrosome protein Cep63 | Cep63 | 251 |
   tumor necrosis factor (ligand) superfamily, member 13 | TNFSF13 | 251 |
   dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis) | DACT1 | 248 |
   heterogeneous nuclear ribonucleoprotein A1 | HNRPA1 | 245 |
   reversion-inducing-cysteine-rich protein with kazal motifs | RECK | 243 |