Skip to main content

Table 1 Genes with highest frequencies in 500 signatures

From: Pathway analysis of gene signatures predicting metastasis of node-negative primary breast cancer

Gene title Gene symbol Frequency
Top 20 core genes from ER-positive tumors   
   KIAA0241 protein KIAA0241 321
   CD44 antigen (homing function and Indian blood group system) CD44 286
   ATP-binding cassette, sub-family C (CFTR/MRP), member 5 ABCC5 251
   serine/threonine kinase 6 STK6 245
   cytochrome c, somatic CYCS 235
   KIAA0406 gene product KIA0406 212
   uridine-cytidine kinase 1-like 1 UCKL1 201
   zinc finger, CCHC domain containing 8 ZCCHC8 188
   Rac GTPase activating protein 1 RACGAP1 186
   staufen, RNA binding protein (Drosophila) STAU 176
   lactamase, beta 2 LACTB2 175
   eukaryotic translation elongation factor 1 alpha 2 EEF1A2 172
   RAE1 RNA export 1 homolog (S. pombe) RAE1 153
   tuftelin 1 TUFT1 150
   zinc finger protein 36, C3H type-like 2 ZFP36L2 150
   origin recognition complex, subunit 6 homolog-like (yeast) ORC6L 143
   zinc finger protein 623 ZNF623 140
   extra spindle poles like 1 ESPL1 139
   transcription elongation factor B (SIII), polypeptide 1 TCEB1 138
   ribosomal protein S6 kinase, 70 kDa, polypeptide 1 RPS6KB1 127
Top 20 core genes from ER-negative tumors   
   zinc finger protein, multitype 2 ZFPM2 445
   ribosomal protein L26-like 1 RPL26L1 372
   hypothetical protein FLJ14346 FLJ14346 372
   mitogen-activated protein kinase-activated protein kinase 2 MAPKAPK2 347
   collagen, type II, alpha 1 COL2A1 340
   muscleblind-like 2 (Drosophila) MBNL2 320
   G protein-coupled receptor 124 GPR124 314
   splicing factor, arginine/serine-rich 11 SFRS11 300
   heterogeneous nuclear ribonucleoprotein A1 HNRPA1 297
   CDC42 binding protein kinase alpha (DMPK-like) CDC42BPA 296
   regulator of G-protein signalling 4 RGS4 276
   transient receptor potential cation channel, subfamily C, member 1 TRPC1 265
   transcription factor 8 (represses interleukin 2 expression) TCF8 263
   chromosome 6 open reading frame 210 C6orf210 262
   dynamin 3 DNM3 260
   centrosome protein Cep63 Cep63 251
   tumor necrosis factor (ligand) superfamily, member 13 TNFSF13 251
   dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis) DACT1 248
   heterogeneous nuclear ribonucleoprotein A1 HNRPA1 245
   reversion-inducing-cysteine-rich protein with kazal motifs RECK 243
  1. The top 20 genes are ranked by their frequency in the 500 signatures of 100 genes for ER-positive and ER-negative tumors (for details see Figure 1).