Figure 4

Enriched Gene Sets for compared pathways operating in MCF-7 and ZR75-1 cells correlated to ER(+)ve and ER(-)ve breast tumor tissues. (a) Unclustered heat map of leading edge subsets in all five groups as analyzed by the GSEA. Rows represent gene sets and columns are genes. This matrix is not clustered, but shows the distribution of genes in each of the gene sets in MCF-7 and ZR75-1 cells in correlation to the ER(+)ve luminal (A and B) and ER(-)ve basal tumors. (b) Enriched gene sets as identified by the GSEA tool. The primary statistic denoting gene enrichment is given by the normalized enrichment score (NES), size is the number of genes in the gene set (in a few cases, the actual number of genes analyzed by the GSEA tool was different), NOM p-val is the nominal P value. For individual gene expression, refer to the cluster heat map (Figure 1D, additional file 3).