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Table 7 Most common and serious Adverse events During TMZ/WBRT treatment according to Common Toxicity Criteria extended by National Cancer Institute, (NCI CTC) in the 59 enrolled patients.

From: Concomitant treatment of brain metastasis with Whole Brain Radiotherapy [WBRT] and Temozolomide [TMZ] is active and improves Quality of Life

  Grade 2   Grade 3   Grade 4  
Toxicity No. pts % No. pts % No. pts %
Neutropenia 15 25 9 15 - -
Thrombocytopenia 4 7 2 3 1 1
Anemia 7 12 8 13 - -
Alopecia 2 3 - - - -
Vomiting 6 10 2 3   
hand and foot syndrome 2 3 - - - -
Headache 5 8 1 1 - -
Nausea 5 8 2 3 - -
Tremor 4 7 2 3 - -
Nerosensory 3 5 - - - -
Fatigue 7 12 2 3 - -
Rash 8 13 3 5 - -