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Table 3 Analysis of clinical predictive factors.

From: Concomitant treatment of brain metastasis with Whole Brain Radiotherapy [WBRT] and Temozolomide [TMZ] is active and improves Quality of Life

Clinical predictive factors for response

 

Tumor control (SD, CR, PR)

Brain progression (PD)

P value

Lung Cancer

16

7

0.363

All the others

29

7

 

Males

25

7

0.321

Females

17

10

 

KPS <70

6

10

< 0.0001

KPS ≥70

29

4

 

No previous chemotherapy

20

5

0.758

Previous chemotherapy

25

9

 

No extracranial disease

25

2

0.012

Extracranial disease

20

12

 

Age > 65 years

6

10

<0.0001

Age ≤65 years

39

4

 

RPA as a predictive factor for response

 

Tumor control (SD, CR, PR)

Brain progression (PD)

P value

RPA 1

14

0

< 0.0001

RPA 2

25

4

 

RPA 3

6

10

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