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Table 3 Analysis of clinical predictive factors.

From: Concomitant treatment of brain metastasis with Whole Brain Radiotherapy [WBRT] and Temozolomide [TMZ] is active and improves Quality of Life

Clinical predictive factors for response
  Tumor control (SD, CR, PR) Brain progression (PD) P value
Lung Cancer 16 7 0.363
All the others 29 7  
Males 25 7 0.321
Females 17 10  
KPS <70 6 10 < 0.0001
KPS ≥70 29 4  
No previous chemotherapy 20 5 0.758
Previous chemotherapy 25 9  
No extracranial disease 25 2 0.012
Extracranial disease 20 12  
Age > 65 years 6 10 <0.0001
Age ≤65 years 39 4  
RPA as a predictive factor for response
  Tumor control (SD, CR, PR) Brain progression (PD) P value
RPA 1 14 0 < 0.0001
RPA 2 25 4  
RPA 3 6 10