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Table 3 Clinical, histologic, and image analysis factors affecting development of invasive disease by image analysis assessment

From: Ductal carcinoma in situ of the breast (DCIS) with heterogeneity of nuclear grade: prognostic effects of quantitative nuclear assessment

Clinical, histologic, and image analysis factors by assessment
Field 1 Field 2
Factorsa P-value Factorsa P-value
Assessment 1   Assessment 6  
Densitometry (Minimum density) 0.001 Texture (Difference entropy) <0.001
Texture (Histogram mean) 0.02 Morphometry (Ellipse major axis) <0.001
   Texture (Angular second moment) 0.001
Assessment 2   Assessment 7  
Texture (Difference entropy) 0.01 Densitometry (Mean density) 0.001
Morphometry (Ellipse minor axis) 0.03 Texture (Difference entropy) 0.001
   Texture (Diagonal moment) 0.04
Assessment 3   Assessment 8  
Texture (Difference entropy) 0.01 Densitometry (Ellipse minor axis) 0.01
   Densitometry (Maximum density) 0.003
   Morphometry (Shape form factor) 0.04
Assessment 4   Assessment 9  
Texture (Sum variance) 0.003 Texture (Difference entropy) <0.001
Texture (Difference entropy) <0.001 Texture (Contrast) <0.001
Texture (Second diagonal moment) <0.001 Morphometry (Ellipse major axis) 0.001
Nuclear grade 0.001 Age 0.02
Morphometry (Ellipse major axis) 0.01 Densitometry (Range density) 0.03
Assessment 5   10  
Densitometry (Minimum density) <0.001 Morphometry (Shape form factor) 0.001
Measured margin <0.001 Texture (Histogram mean) 0.02
Texture (Variance) <0.001 Texture (Difference entropy) 0.01
Texture (Histogram Mean) <0.001 Measured margin 0.05
Texture (Contrast) 0.002   
Field 1 Overall   Field 2 Overall  
Assessment 11   Assessment 12  
Densitometry (Minimum density) 0.005 Texture (Difference entropy) <0.001
Texture (Difference entropy) 0.01 Discriminant classification function <0.001
Texture (Diagonal moment) 0.04 Parenchymal involvement 0.001
Both Fields Overall – Assessment 13    
Texture (Difference entropy)    p < 0.001
Texture (Contrast)    p < 0.001
Texture (Peak transition probability)    p = 0.01
Densitometry (Range density)    p = 0.004
Measured margin    p = 0.05
  1. a Factors significantly (p ≤ 0.05) associated with development of invasive disease, in the order entered into the step-wise forward Cox regression models.