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Table 6 CTLA-4 haplotype frequencies in breast cancer patients and healthy controls

From: Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population

CTLA-4 haplotype Freq. Breast cancer (n = 117) Healthy controls (n = 148) P-value Odds ratio (95% CI)
-1661 -658 -318 +49 CT60      
A C C G A 0.25 22.1% 27.1% 0.19  
A C C A G 0.22 25.5% 19.3% 0.089  
A C C A A 0.20 16.5% 22.5% 0.085  
G C T A A 0.062 8.1% 4.6% 0.081  
A C C G G 0.058 8.0% 4.1% 0.053  
G C C A A 0.052 6.5% 4.2% 0.22  
A T C G A 0.040 1.1% 6.3% 0.0026a 0.17(0.05–0.54)
G C C A G 0.033 3.9% 2.8% 0.50  
A T C A A 0.025 1.2% 3.5% 0.091  
G C T A G 0.016 2.2% 1.1% 0.32  
A T C A G 0.015 0.3% 2.5% 0.034 0.12(0.02–0.92)
A C T A A 0.010 2.0% 0.3% 0.062  
  1. a P = 0.012 after correcting the P-value for multiple testing by Haploview program using 10,000 permutations.