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Table 5 CTLA-4 allele counts and frequencies in breast cancer patients and healthy controls

From: Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population

SNP Breast cancer (n = 117) Healthy controls (n = 148) P-value Odds ratio (95% CI)
  Allele count (minor/major) Allele frequency Allele count (minor/major) Allele frequency   
CTLA-4 -1661G/A# 49/169 22.5% 39/257 13.2% 0.0057 a 1.91 (1.21–3.02)
CTLA-4 -658T/C 6/224 2.6% 40/250 13.8% 0.0000082 b 0.17 (0.08–0.37)
CTLA-4 -318T/C 33/201 14.1% 19/277 6.4% 0.0031 c 2.39 (1.34–4.27)
CTLA-4 +49G/A 79/155 33.8% 116/180 39.2% 0.20  
CTLA-4 CT60G/A 95/139 40.6% 92/204 31.1% 0.023 1.52 (1.06–2.17)
  1. # patients (n = 109), missing (n = 8); controls (n = 148), missing (n = 0)
  2. patients (n = 115), missing (n = 2); controls (n = 145), missing (n = 3)
  3. a P = 0.031, b P = 0.00010 and c P = 0.017 after correcting the P-value for multiple testing by Haploview program using 10,000 permutations.