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Table 5 CTLA-4 allele counts and frequencies in breast cancer patients and healthy controls

From: Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population

SNP

Breast cancer (n = 117)

Healthy controls (n = 148)

P-value

Odds ratio (95% CI)

 

Allele count (minor/major)

Allele frequency

Allele count (minor/major)

Allele frequency

  

CTLA-4 -1661G/A#

49/169

22.5%

39/257

13.2%

0.0057 a

1.91 (1.21–3.02)

CTLA-4 -658T/C†

6/224

2.6%

40/250

13.8%

0.0000082 b

0.17 (0.08–0.37)

CTLA-4 -318T/C

33/201

14.1%

19/277

6.4%

0.0031 c

2.39 (1.34–4.27)

CTLA-4 +49G/A

79/155

33.8%

116/180

39.2%

0.20

 

CTLA-4 CT60G/A

95/139

40.6%

92/204

31.1%

0.023

1.52 (1.06–2.17)

  1. # patients (n = 109), missing (n = 8); controls (n = 148), missing (n = 0)
  2. † patients (n = 115), missing (n = 2); controls (n = 145), missing (n = 3)
  3. a P = 0.031, b P = 0.00010 and c P = 0.017 after correcting the P-value for multiple testing by Haploview program using 10,000 permutations.
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BMC Cancer

ISSN: 1471-2407

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