Table 4 Genotype frequencies of CTLA-4 polymorphisms in breast cancer patients and healthy controls
From: Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population
| Genotype | Frequency, no. (%) | P-value | Odds ratio (95% CI) | ||
|---|---|---|---|---|---|
| Patients (n = 117) | Controls (n = 148) | ||||
| -1661, G/A# | AA | 62 (56.9) | 111 (75.0) | 0.0022 | 0.44 (0.26–0.74) |
| AG | 45 (41.3) | 35 (23.7) | 0.0025 | 2.27 (1.33–3.87) | |
| GG | 2 (1.8) | 2 (1.4) | 0.76 | ||
| -658, T/C† | CC | 109 (94.8) | 105 (72.4) | 0.0000027 | 6.92 (3.08–15.52) |
| TC | 6 (5.2) | 40 (27.6) | 0.0000027 | 0.14 (0.06–0.32) | |
| TT | 0 | 0 | |||
| -318, T/C | CC | 84 (71.8) | 129 (87.2) | 0.0018 | 0.37 (0.20–0.69) |
| TC | 33 (28.2) | 19 (12.8) | 0.0018 | 2.67 (1.44–4.93) | |
| TT | 0 | 0 | |||
| +49, G/A | AA | 48 (41.0) | 55 (37.2) | 0.52 | |
| AG | 59 (50.4) | 70 (47.3) | 0.61 | ||
| GG | 10 (8.6) | 23 (15.5) | 0.090 | ||
| CT60, G/A | AA | 46 (39.3) | 74 (50.0) | 0.080 | |
| AG | 47 (40.2) | 56 (37.8) | 0.70 | ||
| GG | 24 (20.5) | 18 (12.2) | 0.060 | ||