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Table 4 Genotype frequencies of CTLA-4 polymorphisms in breast cancer patients and healthy controls

From: Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population

Genotype   Frequency, no. (%) P-value Odds ratio (95% CI)
   Patients (n = 117) Controls (n = 148)   
-1661, G/A# AA 62 (56.9) 111 (75.0) 0.0022 0.44 (0.26–0.74)
  AG 45 (41.3) 35 (23.7) 0.0025 2.27 (1.33–3.87)
  GG 2 (1.8) 2 (1.4) 0.76  
-658, T/C CC 109 (94.8) 105 (72.4) 0.0000027 6.92 (3.08–15.52)
  TC 6 (5.2) 40 (27.6) 0.0000027 0.14 (0.06–0.32)
  TT 0 0   
-318, T/C CC 84 (71.8) 129 (87.2) 0.0018 0.37 (0.20–0.69)
  TC 33 (28.2) 19 (12.8) 0.0018 2.67 (1.44–4.93)
  TT 0 0   
+49, G/A AA 48 (41.0) 55 (37.2) 0.52  
  AG 59 (50.4) 70 (47.3) 0.61  
  GG 10 (8.6) 23 (15.5) 0.090  
CT60, G/A AA 46 (39.3) 74 (50.0) 0.080  
  AG 47 (40.2) 56 (37.8) 0.70  
  GG 24 (20.5) 18 (12.2) 0.060  
  1. # patients (n = 109), missing (n = 8); controls (n = 148), missing (n = 0)
  2. patients (n = 115), missing (n = 2); controls (n = 145), missing (n = 3)