|
Genotype
|
Cases n
|
%
|
Controls n
|
%
|
Co-dominant model OR 95% CI
|
Recessive model OR 95% CI
|
|---|
|
≤60 years
| | | | | | |
|
N/N
|
16
|
50.0
|
94
|
54.0
| | |
|
N/H
|
10
|
31.2
|
68
|
39.1
|
0.86 (0.37; 2.03)
| |
|
H/H
|
6
|
18.8
|
12
|
6.9
|
2.94 (0.94; 9.15)
|
3.12 (1.06; 9.16)
|
|
Total
|
32
|
100.0
|
174
|
100.0
| | |
|
>60 years
| | | | | | |
|
N/N
|
32
|
54.2
|
33
|
37.9
| | |
|
N/H
|
21
|
35.6
|
39
|
44.8
|
0.56 (0.27; 1.15)
| |
|
H/H
|
6
|
10.2
|
15
|
17.2
|
0.41 (0.14; 1.22)
|
0.54 (0.20; 1.51)
|
|
Total
|
59
|
100.0
|
87
|
100.0
| | |
- Odds Ratios (OR) and 95% Confidence Intervals according to co-dominant and recessive models, estimated using logistic regression models. Interaction among between BRCA2 N372H genotype and age: ORinteraction = 0.17 (95%CI = 0.04–0.76); p = 0.02.
