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Table 2 Distribution of 91 MBC cases not mutated in BRCA genes and 261 male population controls according to the BRCA2 N372H genotype frequencies, stratified by age at diagnosis.

From: Association between the BRCA2N372H variant and male breast cancer risk: a population-based case-control study in Tuscany, Central Italy

Genotype Cases n % Controls n % Co-dominant model OR 95% CI Recessive model OR 95% CI
≤60 years       
N/N 16 50.0 94 54.0   
N/H 10 31.2 68 39.1 0.86 (0.37; 2.03)  
H/H 6 18.8 12 6.9 2.94 (0.94; 9.15) 3.12 (1.06; 9.16)
Total 32 100.0 174 100.0   
>60 years       
N/N 32 54.2 33 37.9   
N/H 21 35.6 39 44.8 0.56 (0.27; 1.15)  
H/H 6 10.2 15 17.2 0.41 (0.14; 1.22) 0.54 (0.20; 1.51)
Total 59 100.0 87 100.0   
  1. Odds Ratios (OR) and 95% Confidence Intervals according to co-dominant and recessive models, estimated using logistic regression models. Interaction among between BRCA2 N372H genotype and age: ORinteraction = 0.17 (95%CI = 0.04–0.76); p = 0.02.