Association between the BRCA2N372H variant and male breast cancer risk: a population-based case-control study in Tuscany, Central Italy

Table 2 Distribution of 91 MBC cases not mutated in BRCA genes and 261 male population controls according to the BRCA2 N372H genotype frequencies, stratified by age at diagnosis.

Genotype	Cases n	%	Controls n	%	Co-dominant model OR 95% CI	Recessive model OR 95% CI
≤60 years
N/N	16	50.0	94	54.0
N/H	10	31.2	68	39.1	0.86 (0.37; 2.03)
H/H	6	18.8	12	6.9	2.94 (0.94; 9.15)	3.12 (1.06; 9.16)
Total	32	100.0	174	100.0
>60 years
N/N	32	54.2	33	37.9
N/H	21	35.6	39	44.8	0.56 (0.27; 1.15)
H/H	6	10.2	15	17.2	0.41 (0.14; 1.22)	0.54 (0.20; 1.51)
Total	59	100.0	87	100.0

Odds Ratios (OR) and 95% Confidence Intervals according to co-dominant and recessive models, estimated using logistic regression models. Interaction among between BRCA2 N372H genotype and age: OR_interaction = 0.17 (95%CI = 0.04–0.76); p = 0.02.

ISSN: 1471-2407