FRA-1 protein overexpression is a feature of hyperplastic and neoplastic breast disorders

BMC Cancer

Table 1 FRA-1 protein expression and localization in normal and neoplastic breast tissues by immunohistochemistry.

	FRA-1 staining score* N(%)					FRA-1 localization**
Histological type	0	1+	2+	3+	4+	N	C	N/C
Normal breast tissues (N = 6)	6 (100)	0 (0)	0 (0)	0 (0)	0 (0)	0	0	0
Fibroadenomas (N = 15)	0 (0)	2(13)	13(87)	0(0)	0(0)	2	11	2
Typical ductal hyperplasias (N = 9)	0 (0)	3 (33)	5 (56)	1 (11)	0 (0)	1	2	6
Atypical ductal hyperplasias (N = 6)	0 (0)	1 (17)	3 (50)	2 (33)	0 (0)	4	1	1
In situ ductal carcinomas (N = 10)	0 (0)	1 (10)	7 (70)	2 (20)	0 (0)	6	1	2
Ductal + Lobular carcinomas (N = 60)	0 (0)	0 (0)	(0)	5 (8)	55(92)	52(0)	0 (0)	8

*FRA-1 staining score was: 0, no. positive cells; +, positive cells; 1+, < 10% of positive cells; 2+, 11–50% of positive cells; 3+, 51–75% of positive cells; 4+, 76–100% positive cells. N, number of cases.
**N=Nuclear, C = Cytoplasmic, N/C = nuclear and cytoplasmic staining

ISSN: 1471-2407