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Table 1 FRA-1 protein expression and localization in normal and neoplastic breast tissues by immunohistochemistry.

From: FRA-1 protein overexpression is a feature of hyperplastic and neoplastic breast disorders

  FRA-1 staining score* N(%) FRA-1 localization**
Histological type 0 1+ 2+ 3+ 4+ N C N/C
Normal breast tissues (N = 6) 6 (100) 0 (0) 0 (0) 0 (0) 0 (0) 0 0 0
Fibroadenomas (N = 15) 0 (0) 2(13) 13(87) 0(0) 0(0) 2 11 2
Typical ductal hyperplasias (N = 9) 0 (0) 3 (33) 5 (56) 1 (11) 0 (0) 1 2 6
Atypical ductal hyperplasias (N = 6) 0 (0) 1 (17) 3 (50) 2 (33) 0 (0) 4 1 1
In situ ductal carcinomas (N = 10) 0 (0) 1 (10) 7 (70) 2 (20) 0 (0) 6 1 2
Ductal + Lobular carcinomas (N = 60) 0 (0) 0 (0) (0) 5 (8) 55(92) 52(0) 0 (0) 8
  1. *FRA-1 staining score was: 0, no. positive cells; +, positive cells; 1+, < 10% of positive cells; 2+, 11–50% of positive cells; 3+, 51–75% of positive cells; 4+, 76–100% positive cells. N, number of cases.
  2. **N=Nuclear, C = Cytoplasmic, N/C = nuclear and cytoplasmic staining