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Table 3 Analysis of 14-3-3 zeta protein expression in OSCCs: Correlation with clinicopathological parameters

From: Over-expression of 14-3-3zeta is an early event in oral cancer

Clinicopathological Features Total Cases 14-3-3 zeta overall Positivity 14-3-3 zeta Cytoplasmic Positivity 14-3-3 zeta Cytoplasmic & Membrane Positivity 14-3-3 zeta Cytoplasmic & Nuclear Positivity
  N n (%) n (%) n (%) n (%)
OSCC 120 95 (79) 77 (65) 8 (6) 10 (8)
Differentiation          
WDSCC 67 51 (76) 43 (64) 4 (6) 4 (6)
MDSCC 47 39 (83) 29 (61) 4 (8) 6 (12)
PDSCC 6 5 (83) 5 (83) 0   0  
Tumor Stage          
T1 20 17 (85) 15 (75) 1 (5) 1 (5)
T2 36 24 (66) 18 (50) 2 (5) 4 (11)
T3 32 27 (84) 19 (60) 5 (15) 3 (9)
T4 32 27 (84) 25 (78) 0   2 (6)
Nodal Status          
N- 66 51 (77) 43 (65) 4 (6) 4 (6)
N+ 54 44 (81) 34 (63) 4 (7) 6 (11)
Habits          
Non consumer 16 12 (75) 10 (62) 1 (6) 1 (6)
Tobacco consumer 104 83 (80) 67 (64) 7 (7) 9 (9)
  1. # OSCCs: Age Range: 29–75 yrs, Median age, 53 yrs; No. of Males: 95; Females:25 ; Non consumers :16; Tobacco consumers (including betel quid usage):104 (p > 0.05) No correlation was observed between 14-3-3ζ protein expression and histopathological grading, tumor stage and nodal status of OSCCs.