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Table 2 Analysis of 14-3-3ζ protein expression in Oral Pre-Malignant lesions: Correlation with clinicopathological parameters

From: Over-expression of 14-3-3zeta is an early event in oral cancer

Clinicopathological Features Total Cases 14-3-3 zeta overall Positivity 14-3-3 zeta Cytoplasmic Positivity 14-3-3 zeta Cytoplasmic & Membrane Positivity 14-3-3 zeta Cytoplasmic & Nuclear Positivity
  N n (%) n (%) n (%) n (%)
Normal 66 25 (38) 25 (38) 0   0  
OPLs 89 61 (69) 46 (52) 8 (9) 7 (8)
Differentiation          
Hyperplasiaa 48 33 (68) 25 (52) 4 (8) 4 (8)
Dysplasia 41 28 (67) 21 (51) 4 (10) 3 (7)
   Mild Dysplasiab 19 10 (53) 9 (47) 1 (5) 0  
   Moderate Dysplasia 14 11 (78) 8 (57) 2 (14) 1 (7)
   Severe Dysplasia 8 7 (87) 4 (50) 1 (12) 2 (25)
Habits          
Non consumer 12 7 (58) 5 (42) 1 (8) 1 (8)
   Tobacco consumer 77 54 (70) 41 (53) 7 (9) 6 (8)
  1. # OPLs: Age range:18–74 yrs, Median age, 44 yrs ; No. of Males :79 ; Females:10; Non consumers :12; Tobacco consumers (including betel quid usage): 77 (p > 0.05);
  2. a Normal/Hyperplasia, p = 0.009;
  3. bMild/Moderate/Severe Dysplasia, p = 0.123