TY - JOUR AU - Krypuy, Michael AU - Ahmed, Ahmed Ashour AU - Etemadmoghadam, Dariush AU - Hyland, Sarah J. AU - deFazio, Anna AU - Fox, Stephen B. AU - Brenton, James D. AU - Bowtell, David D. AU - Dobrovic, Alexander AU - Australian Ovarian Cancer Study Group PY - 2007 DA - 2007/08/31 TI - High resolution melting for mutation scanning of TP53exons 5–8 JO - BMC Cancer SP - 168 VL - 7 IS - 1 AB - p53 is commonly inactivated by mutations in the DNA-binding domain in a wide range of cancers. As mutant p53 often influences response to therapy, effective and rapid methods to scan for mutations in TP53 are likely to be of clinical value. We therefore evaluated the use of high resolution melting (HRM) as a rapid mutation scanning tool for TP53 in tumour samples. SN - 1471-2407 UR - https://doi.org/10.1186/1471-2407-7-168 DO - 10.1186/1471-2407-7-168 ID - Krypuy2007 ER -