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Table 5 Series of patients with recurrent gliomas treated with radio-chemotherapy.

From: Radiotherapeutic alternatives for previously irradiated recurrent gliomas

Author RT-Technique Chemotherapy Pt. Number Histology Tumor size (ml; median) Median Dose (Gy) Median Fraction Size (Gy) Median survival (months) Rate of Severe Toxiticy/Reoperation rate (%)
Arcicasa et al., 1999 CH-EBRT CCNU 24 (7) GBM (AA) - 34.5 1.5 13.7 -
Glass et al., 1997 CH-HSFRT Cisplatin 13 (7) GBM (AA) 14 35–42 (range) 3.5–6 (range) 13.7 -
Lederman et al., 2000 CH-HSFRT Paclitaxel 88 GBM 32.7 18–36 (range) 4–9 (range) 7 11%
Wurm et al., 2006 CH-HSFRT Topotecan 5 (25) III 16.5 30 5 21.3 -
Wurm et al., 2006 CH-HSFRT Topotecan 20 (25) IV 16.5 30 5 7.9