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Table 4 Series of patients with recurrent gliomas treated with I-125 seed implants.

From: Radiotherapeutic alternatives for previously irradiated recurrent gliomas

Author Pt. Number Histology (Median) Dose (Gy) Median survival (months) Rate of Severe Toxiticy/Reoperation rate (%)
Permanent Brachytherapy
Gaspar et al., 1999 37 (22) GBM (AA) 100 10.5 44%
Halligan et al, 1996 22(4) GBM (AA) - 16 5%
Larson et al., 2004 38 GBM 150–500 12.0 10%
Patel ell., 2000 40 GBM 120–160 11.8 0%
Temporary Brachytherapy
Gutin et al., 1987 18 GBM - 13 41%
Leibel et al., 1989 45 GBM 70 12.5 49%
Leibel et al., 1989 50 AA 70 18.7  
Shrieve et al., 1995 32 GBM 50 11.5 44%
Simon et al., 2002 42 GBM 40–60 12.5 24%
Sneed et al, 1997 45 AA 64 12.3 53%
Sneed et al., 1997 66 GBM 64 11.7 46%
Glia Site Temporary Brachytherapy
Chan et al., 2005 24 GBM 53 9.1 33%
Gabayan et al., 2006 80 GBM 60 Gy 8.9 2%
Gabayan et al., 2006 15 Non-GBM 60 Gy 10.9