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Table 3 Multivariate analysis of cause-specific mortality based on 30,989 cases of invasive cancer of the cervix

From: Prognostic value of histopathology and trends in cervical cancer: a SEER population study

Variable Hazard ratio(3) (95% confidence interval) P
Demographic characteristics   
SEER area   
   Central registries 0.95 (0.89–1.01) 0.099
   Western registries 0.97 (0.91–1.03) 0.308
Age at diagnosis 1.01 (1.00–1.01) <0.001
Year of diagnosis 1.00 (1.00–1.01) 0.013
African-American ethnicity (1) 1.14 (1.07–1.22) <0.001
Marital status (married) (1) 0.99 (0.94–1.04) 0.638
Pathology   
Histological type (2)   <0.001
   SCC microinvasive 0.28 (0.20–0.39) <0.001
   Carcinoma not otherwise specified 0.91 (0.79–1.04) 0.168
   Adenocarcinoma excl. mucinous 1.06 (0.98–1.15) 0.126
   Adenosquamous carcinoma 1.35 (1.20–1.51) <0.001
   Mucinous 1.52 (1.23–1.88) <0.001
   Small cell 1.94 (1.58–2.39) <0.001
Histological High grade (1) 2.17 (1.93–2.44) <0.001
Localized stage (1) 0.07 (0.05–0.08) <0.001
Treatments and interactions   
Hysterectomy (1) 0.26 (0.21–0.31) <0.001
Radiotherapy (1) 1.01 (0.92–1.11) 0.810
Hysterectomy * Radiotherapy 2.05 (1.67–2.52) <0.001
High grade * Radiotherapy 0.60 (0.53–0.69) <0.001
Localized stage * Hysterectomy 2.87 (2.17–3.78) <0.001
Localized stage * Radiotherapy 5.24 (4.36–6.29) <0.001
Localized stage * Hysterectomy * Radiotherapy 0.40 (0.28–0.56) <0.001
  1. (1) Binarized variable, coded 1, versus all other levels of the variable including missing.
  2. (2) Reference level = non-microinvasive squamous cell carcinoma (SCC), all types.
  3. (3) Hazard ratio >1 indicates increased risk of dying from cervical cancer.