Prognostic value of histopathology and trends in cervical cancer: a SEER population study

BMC Cancer

Table 3 Multivariate analysis of cause-specific mortality based on 30,989 cases of invasive cancer of the cervix

Variable	Hazard ratio⁽³⁾ (95% confidence interval)	P
Demographic characteristics
SEER area
Central registries	0.95 (0.89–1.01)	0.099
Western registries	0.97 (0.91–1.03)	0.308
Age at diagnosis	1.01 (1.00–1.01)	<0.001
Year of diagnosis	1.00 (1.00–1.01)	0.013
African-American ethnicity ⁽¹⁾	1.14 (1.07–1.22)	<0.001
Marital status (married) ⁽¹⁾	0.99 (0.94–1.04)	0.638
Pathology
Histological type ⁽²⁾		<0.001
SCC microinvasive	0.28 (0.20–0.39)	<0.001
Carcinoma not otherwise specified	0.91 (0.79–1.04)	0.168
Adenocarcinoma excl. mucinous	1.06 (0.98–1.15)	0.126
Adenosquamous carcinoma	1.35 (1.20–1.51)	<0.001
Mucinous	1.52 (1.23–1.88)	<0.001
Small cell	1.94 (1.58–2.39)	<0.001
Histological High grade ⁽¹⁾	2.17 (1.93–2.44)	<0.001
Localized stage ⁽¹⁾	0.07 (0.05–0.08)	<0.001
Treatments and interactions
Hysterectomy ⁽¹⁾	0.26 (0.21–0.31)	<0.001
Radiotherapy ⁽¹⁾	1.01 (0.92–1.11)	0.810
Hysterectomy * Radiotherapy	2.05 (1.67–2.52)	<0.001
High grade * Radiotherapy	0.60 (0.53–0.69)	<0.001
Localized stage * Hysterectomy	2.87 (2.17–3.78)	<0.001
Localized stage * Radiotherapy	5.24 (4.36–6.29)	<0.001
Localized stage * Hysterectomy * Radiotherapy	0.40 (0.28–0.56)	<0.001

⁽¹⁾ Binarized variable, coded 1, versus all other levels of the variable including missing.
⁽²⁾ Reference level = non-microinvasive squamous cell carcinoma (SCC), all types.
⁽³⁾ Hazard ratio >1 indicates increased risk of dying from cervical cancer.

ISSN: 1471-2407