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Table 4 Analysis of polymorphisms and lung cancer risk estimates

From: Polymorphisms in XPC, XPD, XRCC1, and XRCC3 DNA repair genes and lung cancer risk in a population of Northern Spain

Repair Gen SNP Genotype Cases n (%) Controls n (%) Adjusteda OR [95% IC] P P trend
NER XPC PAT -/- 172 (33.3) 190 (35.6) Reference   
    +/- 243 (47.1) 259 (48.6) 1.08 [0.79–1.47] 0.627  
    +/+ 101 (19.6) 84 (15.8) 1.28 [0.85–1.92] 0.229 0.246
  XPD Asp312Asn Asp/Asp 240 (46.5) 260 (48.8) Reference   
    Asp/Asn 221 (42.8) 230 (43.1) 1.01 [0.76–1.35] 0.934  
    Asn/Asn 55 (10.7) 43 (8.1) 1.52 [0.91–2.51] 0.106 0.232
   Lys751Gln Lys/Lys 222 (43.0) 243 (45.6) Reference   
    Lys/Gln 237 (45.9) 240 (45.0) 1.12 [0.84–1.50] 0.437  
    Gln/Gln 57 (11.1) 50 (9.4) 1.38 [0.85–2.25] 0.193 0.181
BER XRCC 1 Arg399Gln Arg/Arg 222 (43.0) 217 (40.7) Reference   
    Arg/Gln 219 (42.5) 234 (43.9) 0.86 [0.63–1.16] 0.320  
    Gln/Gln 75 (14.5) 82 (15.4) 0.87 [0.57–1.31] 0.500 0.672
DSBR XRCC 3 Thr241Met Thr/Thr 168 (41.7) 178 (41.0) Reference   
    Thr/Met 185 (45.9) 196 (45.2) 1.06 [0.76–1.49] 0.724  
    Met/Met 50 (12.4) 60 (13.8) 0.92 [0.56–1.50] 0.898 0.898
  1. a Adjusted by age, gender and cumulative tobacco consumption (in pack-years: ≤ 16.45, > 16.45–53 and > 53)