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Table 2 Clinical characteristics of colorectal cancer patients and GSTT2 genotypes

From: GSTT2 promoter polymorphisms and colorectal cancer risk

  -537 G>A -277T>C -158G>A
  GG (%) GA (%) AA (%) p 1 GA+AA (%) p 2 TT (%) TC (%) CC (%) p 1 TC+CC (%) p 2 TT (%) TC (%) p 2
No. of subjects 127 240 69   309   388 45 3   48   416 20  
Age (years ± SD) 59.1 ± 13.2 58.91 ± 13.0 57.9 ± 12.2 0.83 58.7 ± 12.8 0.76 58.6 ± 13.0 60.0 ± 11.7 66.5 ± 2.1 0.56 60.3 ± 11.5 0.41 58.8 ± 13.0 58.2 ± 11.7 0.85
Sex (M/F)                
   Male 81 (64.8) 151 (63.4) 44 (63.8) 0.97 195 (63.5) 0.8 247 (64.2) 27 (60.0) 2 (100) 0.49 29 (61.7) 0.74 262 (63.4) 14 (73.7) 0.36
   Female 44 (35.2) 87 (36.6) 25 (36.2)   112 (36.5)   138 (35.8) 18 (40.0) -   18 (38.3)   151 (36.6) 5 (26.3)  
Location                
   proxim al 48 (39.3) 84 (35.6) 19 (29.7) 0.43 103 (34.3) 0.33 135 (36.0) 15 (33.3) 1 (50.0) 0.86 16 (34.0) 0.79 141 (35.0) 10 (52.6) 0.18
   distal 74 (60.7) 152 (64.4) 45 (70.3)   197 (65.7)   240 (64.0) 30 (66.7) 1 (50.0)   31 (66.0)   262 (65.0) 9 (47.4)  
MSI status                
   MSI 17 (13.9) 35 (14.8) 10 (14.5) 0.97 45 (14.8) 0.83 52 (13.6) 10 (23.8) - 0.17 10 (22.7) 0.1 59 (14.4) 3 (17.6) 0.71
   MSS 105 (86.1) 201 (85.2) 59 (85.5)   260 (85.2)   331 (86.4) 32 (76.2) 2 (100)   34 (77.3)   351 (85.6) 14 (82.4)  
T-stage                
   T1 - 2 (0.9) 2 (3.1) 0.11 4 (1.3) 0.39 4 (1.1) - - 0.95 - 0.74 4 (1.0) - 0.9
   T2 8 (6.5) 8 (3.4) 2 (3.1)   10 (3.3)   15 (4.0) 3 (6.8) -   3 (6.5)   17 (4.2) 1 (5.3)  
   T3 102 (82.3) 195 (83.0) 56 (86.1)   251 (83.4)   317 (83.6) 34 (77.3) 2 (100)   36 (78.3)   336 (82.8) 17 (89.5)  
   T4 14 (11.3) 30 (12.8) 5 (7.7)   35 (11.6)   42 (11.1) 7 (15.9) -   7 (15.2)   48 (11.8) 1 (5.3)  
N-stage                
   N0 58 (46.8) 119 (50.4) 35 (53.0) 0.31 154 (51.0) 0.54 189 (49.7) 23 (52.3) - 0.13 23 (50.0) 0.55 200 (49.1) 12 (63.2) 0.38
   N1 36 (29.0) 75 (31.8) 14 (21.2)   89 (29.5)   114 (30.0) 9 (20.5) 2 (100)   11 (23.9)   122 (30.0) 3 (15.8)  
   N2 30 (24.2) 42 (17.8) 17 (25.8)   59 (19.5)   77 (20.3) 12 (27.3) -   12 (26.1)   85 (20.9) 4 (21.1)  
M-stage                
   M0 90 (74.4) 182 (78.1) 52 (78.8) 0.69 234 (78.3) 0.39 293 (78.3) 30 (68.2) 1 (50.0) 0.21 31 (67.4) 0.1 311 (77.6) 13 (68.4) 0.35
   M1 31 (25.6) 51 (21.9) 14 (21.2)   65 (21.7)   81 (21.7) 14 (31.8) 1 (50.0)   15 (32.6)   90 (22.4) 6 (31.6)  
TNM stage                
   I 6 (5.0) 10 (4.3) 3 (4.6) 0.94 13 (4.4) 0.69 16 (4.3) 3 (6.8) - 0.37 3 (6.5) 0.2 18 (4.5) 1 (5.3) 0.46
   II 42 (34.7) 93 (40.1) 28 (43.1)   121 (40.7)   145 (39.0) 18 (40.9) -   18 (39.1)   154 (38.6) 9 (47.4)  
   III 42 (34.7) 78 (33.6) 20 (30.8)   98 (33.0)   130 (34.9) 9 (20.5) 1 (50.0)   10 (21.7)   137 (34.3) 3 (15.8)  
   IV 31 (25.6) 51 (22.0) 14 (21.5)   65 (21.9)   81 (21.8) 14 (31.8) 1 (50.0)   15 (32.6)   90 (22.6) 6 (31.6)  
  1. Student's t-test or χ2 test; p 1: Co-dominant model; p 2: Dominant model