A-C. Immunostaining to IFNγ was observed always in the cytoplasm of epithelial cells. Similar immunoreaction was found in benign lesion (A) and in infiltrating carcinomas (C). Cases of in situ carcinoma (B) showed the highest immunoreaction intensity. Bar: 20 μm (A) and 15 μm (B and C). D-F: Immunostaining to IFNγ-Rα is localized in the cytoplasm of epithelial cells in the three breast groups. Similar immunoreaction was found in benign lesion (D) and in in situ patients (E). The reaction intensity was lower in infiltrating carcinomas (F) than in the other two groups. Bar: 15 μm (D and E) and 25 μm (F). G-I: The three sample groups showed a similar immunoreaction to IFNγ-Rβ. Immunostaining is localized in both the peripheral cytoplasm (G) and the nucleus (inset) in benign lesion group. This immunoreaction intensity was similar to that found in the other two groups. Most of in situ samples (H) and infiltrating carcinoma cases (I) showed nuclear immunostainig to IFN-Rβ. Bar: 10 μm (G) and 20 μm (H and I).