TGF-beta receptor 2 downregulation in tumour-associated stroma worsens prognosis and high-grade tumours show more tumour-associated macrophages and lower TGF-beta1 expression in colon carcinoma: a retrospective study

Table 2 Content of tumour-associated macrophages and expression of TGF-β components in tumour and -associated stroma

tumour	TAMs			TGF-β1			TGF-β-R1			TGF-β-R2			Smad3			Smad4
n	low (0–1)	high (2–3)	p value	low (0–1)	high (2–3)	p value	low (0–1)	high (2–3)	p value	neg.	pos.	p value	neg.	pos.	p value	neg.	pos.	p value
low-grade	248	7	<0.001	165	90	0.009	239	16	0.148	245	10	0.278	111	146	0.907	39	214	0.295
high-grade	39	13		44	9		47	7		50	4		22	30		5	47
N0	167	9	0.019	113	63	0.202	163	14	0.581	167	10	0.630	79	99	0.579	35	139	0.004
N+	120	11		96	36		123	9		128	4		54	77		9	122
5 ycrs	87.0	80.0	0.261	85.6	88.8	0.459	86.4	87.0	0.787	87.0	78.6	0.631	86.1	86.6	0.991	92.5	85.4	0.896
5 ydm	19.4	30.0	0.241	18.7	22.6	0.463	19.9	17.4	0.851	19.9	21.4	0.701	19.5	19.9	0.795	17.3	20.7	0.419
stroma	TAMs			TGF-β1			TGF-β-R1			TGF-β-R2			Smad3			Smad4
n	low (0–1)	high (2–3)	p value	low (0–1)	high (2–3)	p value	low (0–1)	high (2–3)	p value	neg.	pos.	p value	neg.	pos.	p value	neg.	pos.	p value
low-grade	152	104	0.134	256	0	n.a.	162	94	1.000	98	158	0.229	140	117	0.653	7	249	1.000
high-grade	26	28		52	0		34	20		25	28		27	26		1	52
N0	59	39	0.141	176	0	n.a.	102	76	0.033	56	121	0.001	98	80	0.627	5	172	1.000
N+	119	93		132	0		94	38		67	65		69	63		3	129
5 ycrs	84.1	87.8	0.897	86.4	n.a.	n.a.	84.7	89.5	0.245	82.3	89.3	0.003	87.5	85.4	0.753	83.3	86.5	0.812
5 ydm	12.6	20.0	0.643	20.7	n.a.	n.a.	24.5	12.3	0.072	25.4	16.6	0.087	21.0	18.9	0.392	14.3	20.2	0.582

5 ycr: 5 year cancer related survival (%); 5 ydm: 5 year rate of distant metastasis (%); n.a.: not available.

ISSN: 1471-2407