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Table 3 Comparison between intestinal permeability before therapy and after the first cycle in patients with or without serious toxicity

From: Gastrointestinal permeability in ovarian cancer and breast cancer patients treated with paclitaxel and platinum

parameter no serious toxicity
(n = 23)
(mean ± SEM)
(95% CI)
(range)
serious toxicity
(n = 13)
(mean ± SEM)
(95% CI)
(range)
p
baseline xylose (%) 19.2 ± 2.0
(15.2 – 23.3)
(2.6 – 45.3)
13.2 ± 2.4
(8.0 – 18.3)
(0.8 – 30.4)
0.05
baseline mannitol (%) 13.5 ± 1.7
(10.0 – 17.0)
(1.8 – 34.2)
7.6 ± 1.4
(4.6 – 10.7)
(0.5 – 18.1)
0.02
baseline sucrose (%) 0.47 ± 0.07
(0.33 – 0.62)
(0.05 – 1.40)
0.30 ± 0.09
(0.11 – 0.49)
(0.05 – 1.17)
0.05
baseline lactulose (%) 0.60 ± 0.10
(0.40 – 0.80)
(0.11 – 2.40)
0.53 ± 0.12
(0.28 – 0.78)
(0.06 – 1.50)
0.26
baseline lactulose/mannitol ratio 0.049 ± 0.005
(0.039 – 0.059)
(0.017 – 0.096)
0.082 ± 0.012
(0.056 – 0.108)
(0.027 – 0.184
0.01
baseline sucrose/mannitol ratio 0.038 ± 0.004
(0.029 – 0.047)
(0.008 – 0.080)
0.038 ± 0.007
(0.023 – 0.053)
(0.013 – 0.098)
0.92
baseline lactulose/xylose ratio 0.032 ± 0.003
(0.026 – 0.039)
(0.014 – 0.063)
0.050 ± 0.009
(0.030 – 0.069)
(0.017 – 0.139)
0.10
baseline sucrose/xylose ratio 0.025 ± 0.003
(0.019 – 0.031)
(0.006 – 0.058)
0.023 ± 0.004
(0.014 – 0.033)
(0.004 – 0.061)
0.64
xylose after the first dose (%) 12.9 ± 1.6
(9.5 – 16.2)
(3.7 – 34.5)
14.5 ± 3.0
(8.1 – 21.0)
(2.2 – 40.7)
0.82
mannitol after the first dose (%) 10.1 ± 1.2
(7.6 – 12.6)
(1.4 – 24.6)
8.6 ± 1.5
(5.4 – 11.7)
(2.1 – 19.2)
0.45
sucrose after the first dose (%) 0.46 ± 0.08
(0.28 – 0.63)
(0.06 – 1.71)
0.70 ± 0.14
(0.41 – 1.00)
(0.10 – 1.60)
0.12
lactulose after the first dose (%) 0.50 ± 0.08
(0.34 – 0.67)
(0.05 – 1.67)
0.87 ± 0.12
(0.62 – 1.13)
(0.50 – 2.08)
0.004
lactulose/mannitol ratio after the first dose 0.061 ± 0.009
(0.042 – 0.081)
(0.010 – 0.144)
0.171 ± 0.057
(0.047 – 0.300)
(0.030 – 0.770)
0.008
sucrose/mannitol ratio after the first dose 0.052 ± 0.009
(0.034 – 0.069)
(0.012 – 0.148)
0.123 ± 0.042
(0.032 – 0.214)
(0.020 – 0.585)
0.03
lactulose/xylose ratio after the first dose 0.050 ± 0.009
(0.031 – 0.068)
(0.007 – 0.180)
0.118 ± 0.039
(0.032 – 0.200)
(0.014 – 0.443)
0.04
sucrose/xylose ratio after the first dose 0.042 ± 0.008
(0.026 – 0.058)
(0.009 – 0.124)
0.085 ± 0.027
(0.027 – 0.143)
(0.010 – 0.336)
0.19
  1. A total of 13 patients experienced a serious toxicity (grade 3 or 4 adverse events) during the first 6 weeks of therapy (grade 3 or 4 leukopenia 6 patients, grade 3 diarrhea 3 patients, grade 3 nausea 3 patients, and grade 3 anemia 1 patient). Shown is the mean ± standard error of the mean (SEM) of respective parameters. 95% confidence intervals (CI) of the mean are highlighted by the bold type, and range is indicated in the parenthesis below.