parameter | no serious toxicity (n = 23) (mean ± SEM) (95% CI) (range) | serious toxicity (n = 13) (mean ± SEM) (95% CI) (range) | p |
---|---|---|---|
baseline xylose (%) | 19.2 ± 2.0 (15.2 – 23.3) (2.6 – 45.3) | 13.2 ± 2.4 (8.0 – 18.3) (0.8 – 30.4) | 0.05 |
baseline mannitol (%) | 13.5 ± 1.7 (10.0 – 17.0) (1.8 – 34.2) | 7.6 ± 1.4 (4.6 – 10.7) (0.5 – 18.1) | 0.02 |
baseline sucrose (%) | 0.47 ± 0.07 (0.33 – 0.62) (0.05 – 1.40) | 0.30 ± 0.09 (0.11 – 0.49) (0.05 – 1.17) | 0.05 |
baseline lactulose (%) | 0.60 ± 0.10 (0.40 – 0.80) (0.11 – 2.40) | 0.53 ± 0.12 (0.28 – 0.78) (0.06 – 1.50) | 0.26 |
baseline lactulose/mannitol ratio | 0.049 ± 0.005 (0.039 – 0.059) (0.017 – 0.096) | 0.082 ± 0.012 (0.056 – 0.108) (0.027 – 0.184 | 0.01 |
baseline sucrose/mannitol ratio | 0.038 ± 0.004 (0.029 – 0.047) (0.008 – 0.080) | 0.038 ± 0.007 (0.023 – 0.053) (0.013 – 0.098) | 0.92 |
baseline lactulose/xylose ratio | 0.032 ± 0.003 (0.026 – 0.039) (0.014 – 0.063) | 0.050 ± 0.009 (0.030 – 0.069) (0.017 – 0.139) | 0.10 |
baseline sucrose/xylose ratio | 0.025 ± 0.003 (0.019 – 0.031) (0.006 – 0.058) | 0.023 ± 0.004 (0.014 – 0.033) (0.004 – 0.061) | 0.64 |
xylose after the first dose (%) | 12.9 ± 1.6 (9.5 – 16.2) (3.7 – 34.5) | 14.5 ± 3.0 (8.1 – 21.0) (2.2 – 40.7) | 0.82 |
mannitol after the first dose (%) | 10.1 ± 1.2 (7.6 – 12.6) (1.4 – 24.6) | 8.6 ± 1.5 (5.4 – 11.7) (2.1 – 19.2) | 0.45 |
sucrose after the first dose (%) | 0.46 ± 0.08 (0.28 – 0.63) (0.06 – 1.71) | 0.70 ± 0.14 (0.41 – 1.00) (0.10 – 1.60) | 0.12 |
lactulose after the first dose (%) | 0.50 ± 0.08 (0.34 – 0.67) (0.05 – 1.67) | 0.87 ± 0.12 (0.62 – 1.13) (0.50 – 2.08) | 0.004 |
lactulose/mannitol ratio after the first dose | 0.061 ± 0.009 (0.042 – 0.081) (0.010 – 0.144) | 0.171 ± 0.057 (0.047 – 0.300) (0.030 – 0.770) | 0.008 |
sucrose/mannitol ratio after the first dose | 0.052 ± 0.009 (0.034 – 0.069) (0.012 – 0.148) | 0.123 ± 0.042 (0.032 – 0.214) (0.020 – 0.585) | 0.03 |
lactulose/xylose ratio after the first dose | 0.050 ± 0.009 (0.031 – 0.068) (0.007 – 0.180) | 0.118 ± 0.039 (0.032 – 0.200) (0.014 – 0.443) | 0.04 |
sucrose/xylose ratio after the first dose | 0.042 ± 0.008 (0.026 – 0.058) (0.009 – 0.124) | 0.085 ± 0.027 (0.027 – 0.143) (0.010 – 0.336) | 0.19 |