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Table 3 Comparison between intestinal permeability before therapy and after the first cycle in patients with or without serious toxicity

From: Gastrointestinal permeability in ovarian cancer and breast cancer patients treated with paclitaxel and platinum

parameter

no serious toxicity

(n = 23)

(mean ± SEM)

(95% CI)

(range)

serious toxicity

(n = 13)

(mean ± SEM)

(95% CI)

(range)

p

baseline xylose (%)

19.2 ± 2.0

(15.2 – 23.3)

(2.6 – 45.3)

13.2 ± 2.4

(8.0 – 18.3)

(0.8 – 30.4)

0.05

baseline mannitol (%)

13.5 ± 1.7

(10.0 – 17.0)

(1.8 – 34.2)

7.6 ± 1.4

(4.6 – 10.7)

(0.5 – 18.1)

0.02

baseline sucrose (%)

0.47 ± 0.07

(0.33 – 0.62)

(0.05 – 1.40)

0.30 ± 0.09

(0.11 – 0.49)

(0.05 – 1.17)

0.05

baseline lactulose (%)

0.60 ± 0.10

(0.40 – 0.80)

(0.11 – 2.40)

0.53 ± 0.12

(0.28 – 0.78)

(0.06 – 1.50)

0.26

baseline lactulose/mannitol ratio

0.049 ± 0.005

(0.039 – 0.059)

(0.017 – 0.096)

0.082 ± 0.012

(0.056 – 0.108)

(0.027 – 0.184

0.01

baseline sucrose/mannitol ratio

0.038 ± 0.004

(0.029 – 0.047)

(0.008 – 0.080)

0.038 ± 0.007

(0.023 – 0.053)

(0.013 – 0.098)

0.92

baseline lactulose/xylose ratio

0.032 ± 0.003

(0.026 – 0.039)

(0.014 – 0.063)

0.050 ± 0.009

(0.030 – 0.069)

(0.017 – 0.139)

0.10

baseline sucrose/xylose ratio

0.025 ± 0.003

(0.019 – 0.031)

(0.006 – 0.058)

0.023 ± 0.004

(0.014 – 0.033)

(0.004 – 0.061)

0.64

xylose after the first dose (%)

12.9 ± 1.6

(9.5 – 16.2)

(3.7 – 34.5)

14.5 ± 3.0

(8.1 – 21.0)

(2.2 – 40.7)

0.82

mannitol after the first dose (%)

10.1 ± 1.2

(7.6 – 12.6)

(1.4 – 24.6)

8.6 ± 1.5

(5.4 – 11.7)

(2.1 – 19.2)

0.45

sucrose after the first dose (%)

0.46 ± 0.08

(0.28 – 0.63)

(0.06 – 1.71)

0.70 ± 0.14

(0.41 – 1.00)

(0.10 – 1.60)

0.12

lactulose after the first dose (%)

0.50 ± 0.08

(0.34 – 0.67)

(0.05 – 1.67)

0.87 ± 0.12

(0.62 – 1.13)

(0.50 – 2.08)

0.004

lactulose/mannitol ratio after the first dose

0.061 ± 0.009

(0.042 – 0.081)

(0.010 – 0.144)

0.171 ± 0.057

(0.047 – 0.300)

(0.030 – 0.770)

0.008

sucrose/mannitol ratio after the first dose

0.052 ± 0.009

(0.034 – 0.069)

(0.012 – 0.148)

0.123 ± 0.042

(0.032 – 0.214)

(0.020 – 0.585)

0.03

lactulose/xylose ratio after the first dose

0.050 ± 0.009

(0.031 – 0.068)

(0.007 – 0.180)

0.118 ± 0.039

(0.032 – 0.200)

(0.014 – 0.443)

0.04

sucrose/xylose ratio after the first dose

0.042 ± 0.008

(0.026 – 0.058)

(0.009 – 0.124)

0.085 ± 0.027

(0.027 – 0.143)

(0.010 – 0.336)

0.19

  1. A total of 13 patients experienced a serious toxicity (grade 3 or 4 adverse events) during the first 6 weeks of therapy (grade 3 or 4 leukopenia 6 patients, grade 3 diarrhea 3 patients, grade 3 nausea 3 patients, and grade 3 anemia 1 patient). Shown is the mean ± standard error of the mean (SEM) of respective parameters. 95% confidence intervals (CI) of the mean are highlighted by the bold type, and range is indicated in the parenthesis below.