Table 1 Characteristics of patients
patient | age (years) | diagnosis | previous chemotherapy | regimen | timing of measurement after the first dose (days from start) | toxicity during first 6 weeks of therapy (grade) | baseline lactulose/mannitol ratio | lactulose/mannitol ratio after the first dose |
|---|---|---|---|---|---|---|---|---|
1 | 52 | EOC (history of BC) | yes | q3w (cisplatin) | 6 | diarrhea (2) | 0.069 | 0.033 |
2 | 66 | EOC | none | q3w | 7 | diarrhea (1) | 0.030 | 0.011 |
3 | 67 | EOC (history of BC) | none | q3w | 7 | none | 0.096 | 0.047 |
4 | 46 | EOC | yes | q3w | 7 | neutropenia (3) | 0.027 | 0.079 |
5 | 52 | EOC | none | q3w | 7 | none | 0.017 | 0.017 |
6 | 39 | unknown primary | none | q3w | 6 | none | 0.044 | 0.021 |
7 | 39 | Krukenberg | yes | q3w | 7 | diarrhea (3) | 0.111 | 0.132 |
8 | 62 | EOC (history of BC) | yes | q3w | 4 | none | 0.090 | 0.018 |
9 | 71 | EOC | yes | q3w | 7 | neutropenia (4) | 0.108 | 0.770 |
10 | 67 | EOC | none | q3w | 7 | leukopenia (2) | 0.061 | 0.129 |
11 | 64 | BC | yes | q3w | 7 | leukopenia (2) | 0.041 | 0.144 |
12 | 56 | EOC | yes | q3w | 7 | none | 0.031 | 0.027 |
13 | 64 | BC | yes | q3w | 7 | none | 0.041 | 0.032 |
14 | 58 | BC | yes | q3w | 7 | diarrhea (1) | 0.026 | 0.132 |
15 | 60 | BC | yes | q3w | 7 | none | 0.033 | 0.054 |
16 | 45 | BC | yes | q3w | 7 | none | 0.033 | 0.110 |
17 | 54 | BC | yes | q3w | 7 | nausea (3) | 0.184 | 0.438 |
18 | 58 | BC | yes | q3w | 7 | neutropenia (3) | 0.038 | 0.057 |
19 | 61 | unknown primary | none | q3w | 6 | diarrhea (2) | 0.055 | 0.063 |
20 | 66 | BC | yes | q3w | 2 | leukopenia (2) | 0.031 | 0.040 |
21 | 46 | EOC (history of BC) | none | q3w | 7 | none | 0.047 | 0.029 |
22 | 52 | EOC (history of BC) | yes | q3w | 7 | leukopenia (2) | 0.063 | 0.119 |
23 | 59 | BC | yes | weekly P+C+T | 7 | anemia (3) | 0.072 | 0.094 |
24 | 78 | BC | yes | weekly P+ T | 7 | diarrhea (3) | 0.094 | 0.133 |
25 | 45 | BC | yes | weekly P+C+T | 7 | none | 0.069 | 0.128 |
26 | 63 | BC | none | weekly P+C | 7 | none | 0.075 | 0.060 |
27 | 36 | Krukenberg | yes | weekly P+C | 7 | leukopenia (3) | 0.072 | 0.106 |
28 | 57 | BC | yes | weekly P+C+T | 7 | none | 0.038 | 0.041 |
29 | 74 | EOC | none | weekly P+C | 2 | nausea (3) | 0.090 | 0.130 |
30 | 41 | BC | yes | weekly P+C+T | 22 | neutropenia (4); stomatitis (3) | 0.038 | 0.030 |
31 | 79 | EOC | none | weekly P+C | 3 | nausea (3) | 0.120 | 0.118 |
32 | 34 | BC | yes | weekly P+C+T | 7 | none | 0.025 | 0.010 |
33 | 63 | BC | yes | weekly P+C+T | 8 | diarrhea (3) | 0.075 | 0.070 |
34 | 55 | BC | yes | weekly P+C+T | 7 | neutropenia (3) | 0.043 | 0.069 |
35 | 62 | BC | yes | weekly P+C+T | 7 | none | 0.082 | 0.099 |
36 | 54 | BC | yes | weekly P+C+T | 7 | none | 0.030 | 0.044 |