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Table 1 Characteristics of patients

From: Gastrointestinal permeability in ovarian cancer and breast cancer patients treated with paclitaxel and platinum

patient age (years) diagnosis previous chemotherapy regimen timing of measurement after the first dose (days from start) toxicity during first 6 weeks of therapy (grade) baseline lactulose/mannitol ratio lactulose/mannitol ratio after the first dose
1 52 EOC (history of BC) yes q3w (cisplatin) 6 diarrhea (2) 0.069 0.033
2 66 EOC none q3w 7 diarrhea (1) 0.030 0.011
3 67 EOC (history of BC) none q3w 7 none 0.096 0.047
4 46 EOC yes q3w 7 neutropenia (3) 0.027 0.079
5 52 EOC none q3w 7 none 0.017 0.017
6 39 unknown primary none q3w 6 none 0.044 0.021
7 39 Krukenberg yes q3w 7 diarrhea (3) 0.111 0.132
8 62 EOC (history of BC) yes q3w 4 none 0.090 0.018
9 71 EOC yes q3w 7 neutropenia (4) 0.108 0.770
10 67 EOC none q3w 7 leukopenia (2) 0.061 0.129
11 64 BC yes q3w 7 leukopenia (2) 0.041 0.144
12 56 EOC yes q3w 7 none 0.031 0.027
13 64 BC yes q3w 7 none 0.041 0.032
14 58 BC yes q3w 7 diarrhea (1) 0.026 0.132
15 60 BC yes q3w 7 none 0.033 0.054
16 45 BC yes q3w 7 none 0.033 0.110
17 54 BC yes q3w 7 nausea (3) 0.184 0.438
18 58 BC yes q3w 7 neutropenia (3) 0.038 0.057
19 61 unknown primary none q3w 6 diarrhea (2) 0.055 0.063
20 66 BC yes q3w 2 leukopenia (2) 0.031 0.040
21 46 EOC (history of BC) none q3w 7 none 0.047 0.029
22 52 EOC (history of BC) yes q3w 7 leukopenia (2) 0.063 0.119
23 59 BC yes weekly P+C+T 7 anemia (3) 0.072 0.094
24 78 BC yes weekly P+ T 7 diarrhea (3) 0.094 0.133
25 45 BC yes weekly P+C+T 7 none 0.069 0.128
26 63 BC none weekly P+C 7 none 0.075 0.060
27 36 Krukenberg yes weekly P+C 7 leukopenia (3) 0.072 0.106
28 57 BC yes weekly P+C+T 7 none 0.038 0.041
29 74 EOC none weekly P+C 2 nausea (3) 0.090 0.130
30 41 BC yes weekly P+C+T 22 neutropenia (4); stomatitis (3) 0.038 0.030
31 79 EOC none weekly P+C 3 nausea (3) 0.120 0.118
32 34 BC yes weekly P+C+T 7 none 0.025 0.010
33 63 BC yes weekly P+C+T 8 diarrhea (3) 0.075 0.070
34 55 BC yes weekly P+C+T 7 neutropenia (3) 0.043 0.069
35 62 BC yes weekly P+C+T 7 none 0.082 0.099
36 54 BC yes weekly P+C+T 7 none 0.030 0.044
  1. Grade 3 or 4 toxicity is highlighted by bold type. BC breast carcinoma; C carboplatin; EOC epithelial ovarian carcinoma; q3w paclitaxel/carboplatin every 3 weeks (cisplatin in patient 1); P paclitaxel; T trastuzumab