Metabolic profiling of human brain metastases using in vivo proton MR spectroscopy at 3T

BMC Cancer

Table 1 Patient characteristic. Treatment and clinical outcome data for all patients with approved MR spectra.

Patient no.	Sex, Age	Primary cancer	Brain mets	Mets other sites than brain	KPS	RPA	Survival (months)	Treatment	Time: diagnosis- 1.MRS (weeks)	Spectral data TE, VOI^1,2
1	F, 52	Breast	Single	Brain only	90	1	13+	S + 3Gyx10	5	32,144¹
2	M, 44	Lung	Single	Brain only*	90	1	10+	S	1	33,144²
3 ^a	F, 47	Lung	Multiple	Brain only	90	1	7+	C	0	32,144¹
4 ^a	F, 45	Breast	Multiple	Mediastinum	100	2	15+	S + 3Gyx10	1	33,144²
5 ^a	F, 48	Breast	Multiple	Skeleton*	100	2	5+	3Gyx10	0	33²
6	F, 57	Lung	Multiple	Intestinal, jejunum	100	2	7	3Gyx10	4	32,144¹
7	M, 63	Lung	Multiple	Lung, skeleton	100	2	6	3Gyx10	2	32,144¹
8	M, 62	Lung	Single	Skeleton	90	2	4.5	S + 3Gyx10	4	33,144²
9	M, 70	Mal. mel.	Multiple	Lung, subcutan*	90	2	2	S + 3Gyx10	3	33 in 2 VOI²
10	F, 36	Breast	Multiple	Liver, skeleton	80	2	9	4Gyx5 (GK)	1	32,144¹
11	F, 47	Breast	Multiple	Liver	80	2	10	3Gyx10	2	32,144¹
12 ^b	F, 66	Breast	Multiple	Brain only	80	2	2	3Gyx10	3	33 in 2 VOI²
13	M, 70	Colon	Single	Liver, lung	80	2	6	S + 4Gyx5	17	33,144¹
14 ^b	F, 80	Lung	Multiple	Brain only	80	2	0.75	4Gyx5	1	33 in 2 VOI²
15 ^a	F, 71	Lung	Multiple	Brain only	80	2	3	3Gyx10	4	33 in 2 VOI²
16	F, 72	Breast	Multiple	Liver, skeleton	60	3	0.5	4Gyx5	2	33,144²
17	M, 69	Colon	Single	Liver, lung	60	3	6	S + 3Gyx10	5	32,144¹
18 ^a	F, 53	Lung	Multiple	Brain only*	60	3	11+	4Gyx5	2	33 in 2 VOI²
19	M, 56	Mal. mel.	Multiple	Epigastrium	60	3	1	No Treatment	2	33² and 32¹
20	F, 63	Breast	Single	Lung, skeleton, lymph node	50	3	0.5	No treatment	0	33,144²
21	F, 71	Mal. mel.	Single	Lung, liver	50	3	1.5	3Gyx10	8	32,144¹

F = female, M = male, mets = metastases, ^a: three MRS follow-up examinations, ^b: two follow-up MRS examinations, *: brain metastases detected before primary cancer, KPS = Karnofsky Performance Score, RPA = Recursive Partitioning Analysis classification, TE = echo time, VOI^1,2 = volume of interest, ¹: voxel size: 15 × 15 × 15 mm³, ²: 10 × 10 × 10 mm³. Mal. mel. = malignant melanoma, GK = gamma knife, S = Brain surgery and histopathologic verification, C = Chemotherapy.

ISSN: 1471-2407