Figure 6
From: HIF2α reduces growth rate but promotes angiogenesis in a mouse model of neuroblastoma
HIF2α promotes neuroblastoma angiogenesis. a) Positive staining of endothelial cells in tumours was revealed by PECAM/CD31 immunohistochemistry and b) by Masson's trichrome staining of tumour sections. Both revealed an increase in blood vessel density in HIF2α tumours versus control ones, whereas the expression of the dominant negative HIF2α(1–485) is associated with an apparent inhibition of the angiogenic process. c) Quantification of blood vessel density represents mean ± SEM of 3NT, 3 HIF2α and 4 HIF2α(1–485) at day 19, and of 11 NT, 11 HIF2α and 6 HIF2α(1–485) tumours and day 28.