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Figure 5 | BMC Cancer

Figure 5

From: HIF2α reduces growth rate but promotes angiogenesis in a mouse model of neuroblastoma

Figure 5

Effect of HIF2α on tumour necrosis and late proliferation. a) Macroscopic observations of tumour nodules and b) histological analyses of Masson's trichrome stained sections reveal extended necrotic areas within day 28-HIF2α(1–485) expressing neuroblastomas, compared to control tumours. Such defects are less often observed up to day 35 in HIF2α nodules. c) PCNA immunohistochemistry reveals, within non-necrotic regions (*), a significantly increased number of proliferating cells in HIF2α tumours, while HIF2α(1–485) neuroblastomas present very few labelled cells at day 28. There is no marked difference in proliferation between the three tumour types at day 19 (insets).

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