Skip to main content

Table 3 Cox proportional model for survival until death from breast cancer at 3 years.

From: Use of immunohistochemical markers can refine prognosis in triple negative breast cancer

    Univariate Full Multivariate Parsimonious
Model Variable RR (95% CI) P RR (95% CI) P RR (95% CI) P
Model 1 CK5/6+ and/or EGFR+ No 1.   1.    
   Yes 2.24 [1.14; 4.39] 0.02 1.20 [0.50; 2.85] 0.68 not present  
  TNP No 1.   1.   1.  
   Yes 4.06 [2.11; 7.82] 0.0001 3.42 [1.37; 8.49] 0.008 4.40 [2.23; 8.69] 0.0001
Model 2 PR No 1.   1.    
   Yes 0.43 [0.23; 0.81] 0.009 0.70 [0.34; 1.45] 0.34 not present  
  CBP No 1.   1.   1.  
   Yes 3.73 [1.88; 7.39] 0.0002 3.13 [1.26; 7.77] 0.01 4.29 [2.12; 8.68] 0.0001
Model 3 ER- HER2- No 1.   1.   1.  
   Yes 4.39 [2.34; 8.23] 0.0001 4.82 [1.95; 11.9] 0.0006 5.38 [2.77; 10.5] 0.0001
  PR No 1.   1.    
   Yes 0.43 [0.23; 0.81] 0.009 0.82 [0.38; 1.76] 0.61 not present  
  CK5/6+ and/or EGFR+ No 1.   1.    
   Yes 2.24 [1.14; 4.39] 0.02 0.99 [0.42; 2.34] 0.98 not present  
  1. All statistical modeling adjust for variables with missing values (see methods). The full multivariate model also includes terms for centre, age of diagnosis, histological grade, tumor size and lymph node. Parsimonious model was assumed when all P-values were below 10%. All three parsimonious models also included terms for tumor size and lymph node status. Parsimonious model-2 also included a term for Histological grade while parsimonious model-3 also included a term for the centre. The total number of subjects is 456. The total number of events is 39 at 3 years.