Table 4 Validity estimates of CDH1, PTGS2, and RASSF1A hypermethylation for discrimination among subtypes of renal cell tumor
From: Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumors
Gene | Tumor subtypes discriminated | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|---|
CDH1 | ccRCC & pRCC vs. chRCC & oncocytoma | 61.3% | 91.3% | 95.0% | 46.7% |
PTGS2 | ccRCC vs. pRCC, chRCC, & oncocytoma | 46.2% | 90.9% | 88.9% | 51.7% |
RASSF1A | pRCC vs. ccRCC, chRCC, & oncocytoma | 76.9% | 75.0% | 35.7% | 94.7% |