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Table 4 Validity estimates of CDH1, PTGS2, and RASSF1A hypermethylation for discrimination among subtypes of renal cell tumor

From: Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumors

Gene Tumor subtypes discriminated Sensitivity Specificity PPV NPV
CDH1 ccRCC & pRCC vs. chRCC & oncocytoma 61.3% 91.3% 95.0% 46.7%
PTGS2 ccRCC vs. pRCC, chRCC, & oncocytoma 46.2% 90.9% 88.9% 51.7%
RASSF1A pRCC vs. ccRCC, chRCC, & oncocytoma 76.9% 75.0% 35.7% 94.7%
  1. ccRCC, clear cell renal cell carcinoma; chRCC, chromophobe renal cell carcinoma; pRCC, papillary renal cell carcinoma; PPV, positive predictive value; NPV, negative predictive value