Table 3 Distribution of methylation levels of cancer-related genes in subtypes of renal cell carcinoma (RCC), oncocytoma, and morphologically normal renal tissue (NRT) [(target gene/ACTB) × 1000 expressed as median (interquartile range)]
From: Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumors
Gene | Clear cell RCC | Papillary RCC | Chromophobe RCC | Oncocytoma | p value* | NRT |
|---|---|---|---|---|---|---|
APC | 0 (0-0) | 0 (0-0) | 0 (0-0) | 0 (0-0) | ns | 0 (0-0) |
ARHI | 942.6 (634.7–1746.6) | 807.2 (623.3–1322.6) | 198.6 (148.7–1575.5) | 930.1 (641.5–1654.5) | ns | 893.5 (574.2–1286.2) |
CDH1 | 3.8 (0.5–12.3) | 3.5 (0–19.3) | 0 (0-0) | 0 (0–1.1) | 0.0007 | 2.3 (0.52–6.72) |
CTNNB1 | 0 (0-0) | 0 (0-0) | 0 (0-0) | 0 (0-0) | ns | 0 (0-0) |
SFN | 1441.4 (947.3–2592.1) | 1048.2 (848.3–1354.5) | 1192.4 (687.9–1477.4) | 1302.5 (738.6–2591.6) | ns | 1088.4 (790.2–1497.1) |
ARF/p14 | 0 (0-0) | 0 (0-0) | 0 (0-0) | 0 (0-0) | ns | 0 (0–0.04) |
CDKN2A/p16 | 0 (0-0) | 0 (0-0) | 0 (0-0) | 0 (0-0) | ns | 0 (0-0) |
RASSF1A | 71.7 (4.7–265.5) | 433.2 (236.4–966.0) | 0 (0–2.7) | 10.6 (2.2–27.5) | 0.0001 | 59.6 (33.1–88.5) |
GSTP1 | 0 (0-0) | 0 (0-0) | 0 (0-0) | 0 (0-0) | ns | 0 (0-0) |
MDR1 | 25.3 (10.5–58.2) | 15.5 (6.0–23.7) | 33.1 (2.6–54.9) | 33.5 (7.9–117.9) | ns | 31.6 (16.6–41.9) |
MTHFR | 556.4 (236.9–965.9) | 349.0 (181.6–561.9) | 572.8 (340.3–887.0) | 667.5 (634.4–1687.9) | ns | 419.7 (305.2–614.3) |
PTGS2 | 72.9 (34.1–222.5) | 17.7 (9.3–43.2) | 6.0 (3.9–49.7) | 16.2 (5.3–28.9) | 0.002 | 54.6 (34.4–90.8) |
TIMP3 | 0 (0-0) | 0 (0-0) | 0 (0-0) | 0 (0-0) | ns | 0 (0-0) |
ESR1 | 6.9 (0–31.3) | 4.4 (2–10.9) | 3.8 (0–19.1) | 12.9 (7.7–76.5) | ns | 15.0 (0.9–35.5) |
ESR2 | 0.6 (0–1.9) | 0 (0–0.4) | 0.3 (0–2.7) | 0 (0–0.5) | ns | 0 (0–0.3) |
FHIT | 0.7 (0–5.6) | 2.6 (0–47.0) | 0.9 (0–4.0) | 0.4 (0–6.6) | ns | 2.0 (0–17.7) |
MGMT | 0 (0-0) | 0 (0-0) | 0 (0-0) | 0 (0-0) | ns | 0 (0-0) |
RARβ2 | 0 (0-0) | 0 (0-0) | 0 (0-0) | 0 (0-0) | ns | 0 (0-0) |