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Table 1 Molecular Profiles of MCF10AT1 sublines (Control, E2, Tam and β-HCH selected). The markers shown based on mRNA expression of genes determined though quantitative RT-PCR. Values represent fold-increase of a marker's expression versus β-actin of a selected subline when compared to control (ethanol vehicle). N = 5–6 for each experiment * p < 0.05 and **p < 0.01 vs. treatment versus control.

From: Promotion of breast cancer by β-Hexachlorocyclohexane in MCF10AT1 cells and MMTV-neu mice

MCF10AT1 sublines selected for 20 passages in DMEM/F12 media containing:
  Control E2 (1 nM) Tam (1 nM) β-HCH (1 uM)
Proto-oncogenes     
cNeu 1.00 1.64* 1.79* 2.73**
Cyclin D1 1.00 1.84* 1.88* 2.50**
p21 1.00 2.05* 1.07 1.19
p27 1.00 2.02* 1.73* 2.80*
Cell Status     
VEGF 1.00 3.12* 0.72 1.34
IGF-IR 1.00 1.99* 2.79* 3.77**
c-met 1.00 2.06** 0.66* 1.26
CK19 1.00 0.78* 0.72* 1.67*
Invasive     
MMP-12 1.00 0.85 0.41* 3.50*
MMP-13 1.00 0.86 18.51** 14.12**
Inflammation     
NFkB 1.00 3.20** 0.24* 2.59**