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Table 3 CYP haplotype frequencies in colorectal cancer cases and control

From: Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1and colorectal cancer risk

Gene

Haplotype1

% frequency (standard error)

p

  

Controls

Cases

 

CYP1B1

ABAAAA

26.85 (0.024)

27.7 (0.022)

0.49

 

AABBAA

24.11 (0.038)

23.6 (0.037)

0.68

 

AABBBA

20.91 (0.033)

21.5 (0.033)

0.63

 

BBBBAA

18.01 (0.031)

17.6 (0.029)

0.73

 

ABBBAA

9.58 (0.035)

8.98 (0.040)

0.46

CYP3A4

ABABBAB

82.64 (0.043)

83.59 (0.026)

0.36

 

ABABBAA

6.70 (0.0071)

6.55 (0.016)

0.83

 

AAABBAB

6.30 (0.043)

5.54 (0.028)

0.24

 

AABBBBB

3.35 (0.0079)

3.32 (0.0086)

0.94

CYP3A5

ABB

90.83 (0.0056)

91.90 (0.0033)

0.17

 

BBA

7.32 (0.0093)

6.66 (0.0027)

0.72

 

BBB

1.14 (0.0095)

0.96 (0.0027)

0.24

  1. 1The order of genotypes is the order of SNPs as listed in Table 1, haplotypes with frequency less than 1% not shown.