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Table 2 CYP genotype frequencies in colorectal cancer cases and controls

From: Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1and colorectal cancer risk

Gene SNP MAF (cases/controls) Genotype Cases Controls Raw OR (95% CI) Adjusted OR (95% CI) P 2
CYP1A2 rs2069522 0.022 AA 2444 2597 1.00 (ref) 1.00 (ref) 0.05
   0.017 AB 115 94 1.30 (0.98–1.72) 1.34 (1.00–1.79)  
    BB 0 0 -- --  
CYP1B1 rs18004401 0.178 AA 1734 1790 1.00 (ref) 1.00 (ref) 0.15
   0.182 AB 739 828 0.92 (0.82–1.04) 0.90 (0.79,1.01)  
    BB 86 76 1.17 (0.85–1.60) 1.13 (0.81,1.57)  
  rs10568361 0.452 AA 519 538 1.00 (0.86–1.17) 1.01 (0.86,1.19) 0.91
   0.453 AB 1277 1365 0.97 (0.86–1.10) 0.98 (0.86,1.12)  
    BB 763 792 1.00 (ref) 1.00 (ref)  
  rs2617266 0.279 AA 203 197 1.11 (0.90–1.36) 1.06 (0.85–1.33) 0.69
   0.271 AB 1022 1062 1.03 (0.92–1.16) 1.05 (0.93–1.18)  
    BB 1333 1430 1.00 (ref) 1.00 (ref)  
  rs2567206 0.280 AA 205 199 1.11 (0.90–1.36) 1.06 (0.85–1.33) 0.71
   0.271 AB 1019 1062 1.03 (0.92–1.15) 1.05 (0.93–1.18)  
    BB 1332 1429 1.00 (ref) 1.00 (ref)  
  rs162558 0.217 AA 1582 1668 1.00 (ref) 1.00 (ref) 0.10
   0.210 AB 847 918 0.97 (0.87–1.09) 1.02 (0.90–1.15)  
    BB 132 108 1.29 (0.99–1.68) 1.36 (1.03–1.80)  
  ss49785885 0 AA 2561 2691 1.00 (ref) 1.00 (ref) 0.50
   0.0004 AB 0 2 0.44 (0–5.60) 0.44 (0–5.60)  
    BB 0 0 -- --  
CYP3A4 rs49869101 0.007 AA 2522 2646 1.00 (ref) 1.00 (ref) 0.56
   0.007 AB 38 40 1.00 (0.64–1.56) 1.15 (0.72,1.86)  
    BB 0 0 -- --  
  rs2242480 0.089 AA 24 26 0.95 (0.55–1.67) 0.94 (0.53–1.67) 0.36
   0.097 AB 410 471 0.90 (0.78–1.04) 0.89 (0.77–1.04)  
    BB 2127 2198 1.00 (ref) 1.00 (ref)  
  rs2687116 0.035 AA 2385 2505 1.00 (ref) 1.00 (ref) 0.98
   0.036 AB 173 187 0.97 (0.78–1.20) 0.98 (0.78–1.22)  
    BB 3 3 1.05 (0.21–5.21) 1.00 (0.19–5.26)  
  rs49869071 0.0006 AA 0 0 -- -- 0.28
   0.0002 AB 3 1 3.16 (0.33–30.37) 3.32 (0.32–34.09)  
    BB 2554 2688 1.00 (ref) 1.00 (ref)  
  rs12721636 0.0008 AA 0 0 -- -- 0.19
   0.0004 AB 4 2 2.11 (0.39–11.51) 2.10 (0.30–23.29)  
    BB 2556 2691 1.00 (ref) 1.00 (ref)  
  rs2740574 0.034 AA 2389 2508 1.00 (ref) 1.00 (ref) 0.94
   0.035 AB 170 181 0.99 (0.79–1.22) 0.99 (0.78–1.24)  
    BB 2 3 0.70 (0.12–4.19) 0.73 (0.12–4.66)  
  rs11773597 0.066 AA 12 13 0.97 (0.44–2.13) 1.08 (0.48–2.43) 0.91
   0.067 AB 312 335 0.98 (0.83–1.15) 0.97 (0.81–1.15)  
    BB 2237 2347 1.00 (ref) 1.00 (ref)  
CYP3A5 rs15524 0.076 AA 2186 2261 1.00 (ref) 1.00 (ref) 0.24
   0.085 AB 360 408 0.91 (0.78–1.06) 0.92 (0.79–1.08)  
    BB 15 24 0.65 (0.34–1.24) 0.62 (0.31–1.21)  
  ss497858861 0.004 AA 1 0 1.05 (0.03-∞) 1.05 (0.03-∞) 0.06
   0.007 AB 20 36 0.58 (0.34–1.01) 0.57 (0.32–1.02)  
    BB 2539 2655 1.00 (ref) 1.00 (ref)  
  rs776746 0.067 AA 12 16 0.78 (0.37–1.65) 0.75 (0.35–1.63) 0.56
   0.073 AB 320 363 0.92 (0.78–1.08) 0.93 (0.79–1.10)  
    BB 2225 2312 1.00 (ref) 1.00 (ref)  
CYP11A1 rs2073475 0.155 AA 64 62 1.11 (0.77–1.58) 1.09 (0.75–1.58) 0.43
   0.146 AB 667 661 1.08 (0.95–1.22) 1.09 (0.95–1.24)  
    BB 1829 1958 1.00 (ref) 1.00 (ref)  
CYP17A1 rs743572 0.379 AA 995 1045 1.00 (ref) 1.00 (ref) 0.86
   0.383 AB 1192 1234 1.01 (0.90–1.14) 1.00 (0.88–1.13)  
    BB 374 416 0.94 (0.80–1.11) 0.96 (0.80–1.14)  
CYP19A1 rs10046 0.472 AA 714 755 1.00 (ref) 1.00 (ref) 0.37
   0.467 AB 1272 1364 0.99 (0.87–1.12) 1.00 (0.88–1.15)  
    BB 572 575 1.05 (0.90–1.23) 1.11 (0.94–1.30)  
  1. MA, minor allele; OR, odds ratio; CI, confidence interval; p, likelihood ratio test p-value; A, B, strand specific allele designations defined in Table 1; 1Hum Mol Genet. 2006 Nov 1;15(21):3263-71. 2unadjusted p-values, adjusted p = 1.0 (not shown)