Table 2 CYP genotype frequencies in colorectal cancer cases and controls
Gene | SNP | MAF (cases/controls) | Genotype | Cases | Controls | Raw OR (95% CI) | Adjusted OR (95% CI) | P 2 |
|---|---|---|---|---|---|---|---|---|
CYP1A2 | rs2069522 | 0.022 | AA | 2444 | 2597 | 1.00 (ref) | 1.00 (ref) | 0.05 |
0.017 | AB | 115 | 94 | 1.30 (0.98–1.72) | 1.34 (1.00–1.79) | |||
BB | 0 | 0 | -- | -- | ||||
CYP1B1 | rs18004401 | 0.178 | AA | 1734 | 1790 | 1.00 (ref) | 1.00 (ref) | 0.15 |
0.182 | AB | 739 | 828 | 0.92 (0.82–1.04) | 0.90 (0.79,1.01) | |||
BB | 86 | 76 | 1.17 (0.85–1.60) | 1.13 (0.81,1.57) | ||||
rs10568361 | 0.452 | AA | 519 | 538 | 1.00 (0.86–1.17) | 1.01 (0.86,1.19) | 0.91 | |
0.453 | AB | 1277 | 1365 | 0.97 (0.86–1.10) | 0.98 (0.86,1.12) | |||
BB | 763 | 792 | 1.00 (ref) | 1.00 (ref) | ||||
rs2617266 | 0.279 | AA | 203 | 197 | 1.11 (0.90–1.36) | 1.06 (0.85–1.33) | 0.69 | |
0.271 | AB | 1022 | 1062 | 1.03 (0.92–1.16) | 1.05 (0.93–1.18) | |||
BB | 1333 | 1430 | 1.00 (ref) | 1.00 (ref) | ||||
rs2567206 | 0.280 | AA | 205 | 199 | 1.11 (0.90–1.36) | 1.06 (0.85–1.33) | 0.71 | |
0.271 | AB | 1019 | 1062 | 1.03 (0.92–1.15) | 1.05 (0.93–1.18) | |||
BB | 1332 | 1429 | 1.00 (ref) | 1.00 (ref) | ||||
rs162558 | 0.217 | AA | 1582 | 1668 | 1.00 (ref) | 1.00 (ref) | 0.10 | |
0.210 | AB | 847 | 918 | 0.97 (0.87–1.09) | 1.02 (0.90–1.15) | |||
BB | 132 | 108 | 1.29 (0.99–1.68) | 1.36 (1.03–1.80) | ||||
ss49785885 | 0 | AA | 2561 | 2691 | 1.00 (ref) | 1.00 (ref) | 0.50 | |
0.0004 | AB | 0 | 2 | 0.44 (0–5.60) | 0.44 (0–5.60) | |||
BB | 0 | 0 | -- | -- | ||||
CYP3A4 | rs49869101 | 0.007 | AA | 2522 | 2646 | 1.00 (ref) | 1.00 (ref) | 0.56 |
0.007 | AB | 38 | 40 | 1.00 (0.64–1.56) | 1.15 (0.72,1.86) | |||
BB | 0 | 0 | -- | -- | ||||
rs2242480 | 0.089 | AA | 24 | 26 | 0.95 (0.55–1.67) | 0.94 (0.53–1.67) | 0.36 | |
0.097 | AB | 410 | 471 | 0.90 (0.78–1.04) | 0.89 (0.77–1.04) | |||
BB | 2127 | 2198 | 1.00 (ref) | 1.00 (ref) | ||||
rs2687116 | 0.035 | AA | 2385 | 2505 | 1.00 (ref) | 1.00 (ref) | 0.98 | |
0.036 | AB | 173 | 187 | 0.97 (0.78–1.20) | 0.98 (0.78–1.22) | |||
BB | 3 | 3 | 1.05 (0.21–5.21) | 1.00 (0.19–5.26) | ||||
rs49869071 | 0.0006 | AA | 0 | 0 | -- | -- | 0.28 | |
0.0002 | AB | 3 | 1 | 3.16 (0.33–30.37) | 3.32 (0.32–34.09) | |||
BB | 2554 | 2688 | 1.00 (ref) | 1.00 (ref) | ||||
rs12721636 | 0.0008 | AA | 0 | 0 | -- | -- | 0.19 | |
0.0004 | AB | 4 | 2 | 2.11 (0.39–11.51) | 2.10 (0.30–23.29) | |||
BB | 2556 | 2691 | 1.00 (ref) | 1.00 (ref) | ||||
rs2740574 | 0.034 | AA | 2389 | 2508 | 1.00 (ref) | 1.00 (ref) | 0.94 | |
0.035 | AB | 170 | 181 | 0.99 (0.79–1.22) | 0.99 (0.78–1.24) | |||
BB | 2 | 3 | 0.70 (0.12–4.19) | 0.73 (0.12–4.66) | ||||
rs11773597 | 0.066 | AA | 12 | 13 | 0.97 (0.44–2.13) | 1.08 (0.48–2.43) | 0.91 | |
0.067 | AB | 312 | 335 | 0.98 (0.83–1.15) | 0.97 (0.81–1.15) | |||
BB | 2237 | 2347 | 1.00 (ref) | 1.00 (ref) | ||||
CYP3A5 | rs15524 | 0.076 | AA | 2186 | 2261 | 1.00 (ref) | 1.00 (ref) | 0.24 |
0.085 | AB | 360 | 408 | 0.91 (0.78–1.06) | 0.92 (0.79–1.08) | |||
BB | 15 | 24 | 0.65 (0.34–1.24) | 0.62 (0.31–1.21) | ||||
ss497858861 | 0.004 | AA | 1 | 0 | 1.05 (0.03-∞) | 1.05 (0.03-∞) | 0.06 | |
0.007 | AB | 20 | 36 | 0.58 (0.34–1.01) | 0.57 (0.32–1.02) | |||
BB | 2539 | 2655 | 1.00 (ref) | 1.00 (ref) | ||||
rs776746 | 0.067 | AA | 12 | 16 | 0.78 (0.37–1.65) | 0.75 (0.35–1.63) | 0.56 | |
0.073 | AB | 320 | 363 | 0.92 (0.78–1.08) | 0.93 (0.79–1.10) | |||
BB | 2225 | 2312 | 1.00 (ref) | 1.00 (ref) | ||||
CYP11A1 | rs2073475 | 0.155 | AA | 64 | 62 | 1.11 (0.77–1.58) | 1.09 (0.75–1.58) | 0.43 |
0.146 | AB | 667 | 661 | 1.08 (0.95–1.22) | 1.09 (0.95–1.24) | |||
BB | 1829 | 1958 | 1.00 (ref) | 1.00 (ref) | ||||
CYP17A1 | rs743572 | 0.379 | AA | 995 | 1045 | 1.00 (ref) | 1.00 (ref) | 0.86 |
0.383 | AB | 1192 | 1234 | 1.01 (0.90–1.14) | 1.00 (0.88–1.13) | |||
BB | 374 | 416 | 0.94 (0.80–1.11) | 0.96 (0.80–1.14) | ||||
CYP19A1 | rs10046 | 0.472 | AA | 714 | 755 | 1.00 (ref) | 1.00 (ref) | 0.37 |
0.467 | AB | 1272 | 1364 | 0.99 (0.87–1.12) | 1.00 (0.88–1.15) | |||
BB | 572 | 575 | 1.05 (0.90–1.23) | 1.11 (0.94–1.30) |