Table 1 Pathways affected by ST-3 over-expression in MDA-MB-231*
pathway name | accession | gene name | fold change | pathway name | accession | gene name | fold change |
|---|---|---|---|---|---|---|---|
MAPK signalling pathway | Â | Â | Wnt signalling pathway | Â | Â | ||
| Â | NM_004630 | MAP4K2 | 3.7 | Â | NM_005044 | PRKX | -2.1 |
| Â | NM_016151 | thousand and one amino acid protein kinase | 2.6 | Â | NM_004423 | DVL3 | 2.5 |
| Â | NM_002524 | NRAS | 2.3 | Â | NM_002335 | LRP5 | -2.0 |
| Â | AF188611 | HSPA5 | -2.1 | Â | NM_003507 | FZD7 | 2.4 |
| Â | NM_005044 | PRKX | -2.1 | Â | BC002646 | JUN | -2.2 |
| Â | M54968 | KRAS2 | -2.1 | Â | NM_002760 | PRKY | 3.0 |
| Â | NM_006609 | MAP3K2 | -2.0 | Â | BC011655 | CTBP1 | 7.3 |
| Â | NM_006256 | PKN2 | 5.3 | Â | NM_002731 | PRKACB | 2.7 |
| Â | BC002646 | JUN | -2.2 | Ribosome | Â | Â | Â |
| Â | NM_007181 | MAP4K1 | 3.4 | Â | BF570115 | RPLP0 | 2.7 |
| Â | NM_001791 | CDC42 | 5.7 | Â | AK093246 | RPL13 | 2.5 |
| Â | NM_000719 | CACNA1C | 2.8 | Â | BC022357 | RPL17 | 2.0 |
| Â | AL050044 | GADD45B | 2.3 | Â | NM_001022 | RPS19 | 5.5 |
| Â | BC003623 | YWHAZ | 6.7 | Â | NM_016093 | RPL26L1 | 2.3 |
| Â | AK124299 | PPM1A | 2.1 | Â | NM_001017 | RPS13 | 9.1 |
| Â | AF233453 | PRKCBP1 | 2.4 | Apoptosis | Â | Â | Â |
| Â | NM_003010 | MAP2K4 | 2.6 | Â | NM_003844 | TNFRSF10A | -2.2 |
| Â | NM_002760 | PRKY | 3.0 | Â | NM_006218 | PIK3CA | 2.0 |
| Â | NM_002731 | PRKACB | 2.7 | Â | NM_000633 | BCL2 | 2.4 |
| Â | NM_002609 | PDGFRB | 3.3 | Â | U84408 | MYD88 | 3.2 |
Cell cycle | Â | Â | Â | Â | NM_002731 | PRKACB | 2.7 |
| Â | BC039904 | HDAC4 | 3.0 | Jak-STAT signalling pathway | Â | Â | |
| Â | BC008026 | Â | 2.9 | Â | NM_001560 | IL13RA1 | 2.9 |
| Â | NM_005915 | MCM6 | 2.1 | Â | NM_006218 | PIK3CA | 2.0 |
| Â | NM_004725 | BUB3 | 3.6 | Â | BC030949 | PTPN11 | 2.6 |
| Â | NM_000075 | CDK4 | 2.4 | Â | NM_000418 | IL4R | 2.5 |
| Â | NM_004219 | PTTG1 | 3.4 | Â | BC028068 | JAK3 | -2.2 |
| Â | NM_031966 | CCNB1 | 2.0 | Ubiquitin mediated proteolysis | Â | Â | |
| Â | NM_001786 | CDC2 | 2.8 | Â | NM_003334 | UBE1 | -2.1 |
| Â | AL050044 | GADD45B | 2.3 | Â | NM_181838 | UBE2D2 | 3.1 |
| Â | NM_004064 | CDKN1B | 2.4 | Â | AB012109 | ANAPC10 | 2.4 |
| Â | NM_006607 | PTTG2 | 2.6 | Â | NM_033632 | FBXW7 | 2.7 |
| Â | BC027989 | CDK6 | 2.6 | Integrin-mediated cell adhesion | Â | Â | |
* analysed by BioRag | Â | Â | Â | NM_005167 | RHOC | 2.4 | |
| Â | Â | Â | Â | Â | NM_001791 | CDC42 | 5.7 |
| Â | Â | Â | Â | Â | NM_016848 | SHC3 | 2.2 |