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Figure 4 | BMC Cancer

Figure 4

From: Stromelysin-3 over-expression enhances tumourigenesis in MCF-7 and MDA-MB-231 breast cancer cell lines: involvement of the IGF-1 signalling pathway

Figure 4

ST-3 induced increase of tumour volume is dependent on the presence of growth factors in vivo. Tumour volume in relation to the day of surgery is shown from A) MDA-MB-231 cell clones delivered with complete matrigel, B) MDA-MB-231 cell clones applied in growth factor depleted matrigel, C) MCF-7 cell clones injected with complete matrigel and D) MCF-7 cells applied with growth factor depleted matrigel. A pool of equal parts of three cell clones (total number: 2 × 106) was injected in a volume of 50 μl of (depleted) matrigel into the mammary fatpad of nude mice. Tumour volume was monitored twice a week. One week prior to MCF-7 cell transplantation, animals received oestrogen pellets subcutanously. Groups included eight animals each. Stars indicate a p-value ≤ 0.05.

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