From: Case-only study of interactions between metabolic enzymes and smoking in colorectal cancer
Genotype | Cigarette smoking | ||||||
---|---|---|---|---|---|---|---|
 | Non-smoker | Smoker | COR (95%CI)* | Smoking history (pack-years) | |||
 |  |  |  | ≤ 35 | COR (95%CI) * | > 35 | COR (95%CI)* |
CYP1A2 C734A | Â | Â | Â | Â | Â | Â | Â |
   AA | 50 | 29 | 1.00(ref.) | 17 | 1.00(ref.) | 12 | 1.00(ref.) |
   CA+CC | 72 | 53 | 1.04(0.44–2.50) | 33 | 1.13(0.42~3.01) | 18 | 0.95(0.31~2.93) |
CYP1B1 C1294G | Â | Â | Â | Â | Â | Â | Â |
   CC | 82 | 47 | 1.00(ref.) | 31 | 1.00(ref.) | 16 | 1.00(ref.) |
   CG+GG | 40 | 35 | 2.62(1.01–6.72)# | 19 | 1.92(0.72~5.11) | 15 | 3.47(1.12~10.80)# |
CYP2E1 C-1019T | Â | Â | Â | Â | Â | Â | Â |
   CC | 60 | 31 | 1.00(ref.) | 18 | 1.00(ref.) | 12 | 1.00(ref.) |
   CT+TT | 62 | 51 | 1.83(0.76–4.40) | 32 | 2.42(0.91~6.46) | 18 | 1.49(0.49~4.53) |
GSTM1 | Â | Â | Â | Â | Â | Â | Â |
   Present | 52 | 32 | 1.00(ref.) | 19 | 1.00(ref.) | 12 | 1.00(ref.) |
   Null | 70 | 50 | 1.53(0.62–3.75) | 31 | 1.45(0.55~3.83) | 18 | 1.77(0.58~5.44) |
GSTT1 | Â | Â | Â | Â | Â | Â | Â |
   Present | 94 | 59 | 1.00(ref.) | 36 | 1.00(ref.) | 21 | 1.00(ref.) |
   Null | 28 | 23 | 1.32(0.49–3.51) | 14 | 1.41(0.49~4.10) | 9 | 1.79(0.53~6.10) |
SULT1A1 | Â | Â | Â | Â | Â | Â | Â |
   *1/*1 | 106 | 72 | 1.00(ref.) | 45 | 1.00(ref.) | 25 | 1.00(ref.) |
   *1/*2,*2/*2 | 17 | 11 | 0.53(0.16–1.69) | 5 | 0.41(0.11~1.60) | 6 | 0.65(0.16~2.66) |