Skip to main content

Table 4 Gene-environment interactions for combination of metabolic enzymes and cigarette smoking in CRC

From: Case-only study of interactions between metabolic enzymes and smoking in colorectal cancer

Genotype

Cigarette smoking

 

Non-smoker

Smoker

COR (95%CI)*

Smoking history (pack-years)

    

≤ 35

COR (95%CI) *

> 35

COR (95%CI)*

CYP1A2 C734A

       

   AA

50

29

1.00(ref.)

17

1.00(ref.)

12

1.00(ref.)

   CA+CC

72

53

1.04(0.44–2.50)

33

1.13(0.42~3.01)

18

0.95(0.31~2.93)

CYP1B1 C1294G

       

   CC

82

47

1.00(ref.)

31

1.00(ref.)

16

1.00(ref.)

   CG+GG

40

35

2.62(1.01–6.72)#

19

1.92(0.72~5.11)

15

3.47(1.12~10.80)#

CYP2E1 C-1019T

       

   CC

60

31

1.00(ref.)

18

1.00(ref.)

12

1.00(ref.)

   CT+TT

62

51

1.83(0.76–4.40)

32

2.42(0.91~6.46)

18

1.49(0.49~4.53)

GSTM1

       

   Present

52

32

1.00(ref.)

19

1.00(ref.)

12

1.00(ref.)

   Null

70

50

1.53(0.62–3.75)

31

1.45(0.55~3.83)

18

1.77(0.58~5.44)

GSTT1

       

   Present

94

59

1.00(ref.)

36

1.00(ref.)

21

1.00(ref.)

   Null

28

23

1.32(0.49–3.51)

14

1.41(0.49~4.10)

9

1.79(0.53~6.10)

SULT1A1

       

   *1/*1

106

72

1.00(ref.)

45

1.00(ref.)

25

1.00(ref.)

   *1/*2,*2/*2

17

11

0.53(0.16–1.69)

5

0.41(0.11~1.60)

6

0.65(0.16~2.66)

  1. * Unconditional logistic regression adjusted for gender, age and alcohol consumption; # P < 0.05