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Table 4 Gene-environment interactions for combination of metabolic enzymes and cigarette smoking in CRC

From: Case-only study of interactions between metabolic enzymes and smoking in colorectal cancer

Genotype Cigarette smoking
  Non-smoker Smoker COR (95%CI)* Smoking history (pack-years)
     ≤ 35 COR (95%CI) * > 35 COR (95%CI)*
CYP1A2 C734A        
   AA 50 29 1.00(ref.) 17 1.00(ref.) 12 1.00(ref.)
   CA+CC 72 53 1.04(0.44–2.50) 33 1.13(0.42~3.01) 18 0.95(0.31~2.93)
CYP1B1 C1294G        
   CC 82 47 1.00(ref.) 31 1.00(ref.) 16 1.00(ref.)
   CG+GG 40 35 2.62(1.01–6.72)# 19 1.92(0.72~5.11) 15 3.47(1.12~10.80)#
CYP2E1 C-1019T        
   CC 60 31 1.00(ref.) 18 1.00(ref.) 12 1.00(ref.)
   CT+TT 62 51 1.83(0.76–4.40) 32 2.42(0.91~6.46) 18 1.49(0.49~4.53)
GSTM1        
   Present 52 32 1.00(ref.) 19 1.00(ref.) 12 1.00(ref.)
   Null 70 50 1.53(0.62–3.75) 31 1.45(0.55~3.83) 18 1.77(0.58~5.44)
GSTT1        
   Present 94 59 1.00(ref.) 36 1.00(ref.) 21 1.00(ref.)
   Null 28 23 1.32(0.49–3.51) 14 1.41(0.49~4.10) 9 1.79(0.53~6.10)
SULT1A1        
   *1/*1 106 72 1.00(ref.) 45 1.00(ref.) 25 1.00(ref.)
   *1/*2,*2/*2 17 11 0.53(0.16–1.69) 5 0.41(0.11~1.60) 6 0.65(0.16~2.66)
  1. * Unconditional logistic regression adjusted for gender, age and alcohol consumption; # P < 0.05