Case-only study of interactions between metabolic enzymes and smoking in colorectal cancer

BMC Cancer

Table 3 Gene-gene interactions for combinations of metabolic enzymes genotypes in CRC

Genotype	CYP1A2 C734A	AA	CC+CA	COR(95%CI)*	P-value
GSTM1
Present		37	47	1.00 (Ref.)	0.14
Null		42	78	1.56(0.86–2.82)
GSTT1
Present		61	92	1.00 (Ref.)	0.59
Null		18	33	1.21(0.62–2.36)
SULT1A1
1/1		68	109	1.00 (Ref.)	0.86
1/2,/2		11	16	0.93(0.40–2.15)
	CYP1B1C1294G	CC	CG+GG	COR(95%CI)*	P-value
GSTM1
Present		50	34	1.00 (Ref.)	0.16
Null		78	40	0.65(0.35–1.19)
GSTT1
Present		92	69	1.00 (Ref.)	0.08
Null		36	15	0.52(0.25–1.08)
SULT1A1
1/1		117	59	1.00 (Ref.)	0.02
1/2,/2		13	15	2.67(1.14–6.27)
	CYP2E1 C-1019T	CC	CT+TT	COR(95%CI)*	P-value
GSTM1
Present		33	51	1.00 (Ref.)	0.23
Null		58	62	0.70(0.39–1.26)
GSTT1
Present		66	87	1.00 (Ref.)	0.42
Null		25	26	0.76(0.40–1.47)
SULT1A1
1/1		83	94	1.00 (Ref.)	0.12
1/2,/2		8	19	2.05(0.82–5.11)

* Unconditional logistic regression adjusted for gender, age, cigarette smoking and alcohol consumption.

ISSN: 1471-2407