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Table 3 Gene-gene interactions for combinations of metabolic enzymes genotypes in CRC

From: Case-only study of interactions between metabolic enzymes and smoking in colorectal cancer

Genotype CYP1A2 C734A AA CC+CA COR(95%CI)* P-value
GSTM1      
   Present   37 47 1.00 (Ref.) 0.14
   Null   42 78 1.56(0.86–2.82)  
GSTT1      
   Present   61 92 1.00 (Ref.) 0.59
   Null   18 33 1.21(0.62–2.36)  
SULT1A1      
   *1/*1   68 109 1.00 (Ref.) 0.86
   *1/*2,*/*2   11 16 0.93(0.40–2.15)  
  CYP1B1C1294G CC CG+GG COR(95%CI)* P-value
GSTM1      
   Present   50 34 1.00 (Ref.) 0.16
   Null   78 40 0.65(0.35–1.19)  
GSTT1      
   Present   92 69 1.00 (Ref.) 0.08
   Null   36 15 0.52(0.25–1.08)  
SULT1A1      
   *1/*1   117 59 1.00 (Ref.) 0.02
   *1/*2,*/*2   13 15 2.67(1.14–6.27)  
  CYP2E1 C-1019T CC CT+TT COR(95%CI)* P-value
GSTM1      
   Present   33 51 1.00 (Ref.) 0.23
   Null   58 62 0.70(0.39–1.26)  
GSTT1      
   Present   66 87 1.00 (Ref.) 0.42
   Null   25 26 0.76(0.40–1.47)  
SULT1A1      
   *1/*1   83 94 1.00 (Ref.) 0.12
   *1/*2,*/*2   8 19 2.05(0.82–5.11)  
  1. * Unconditional logistic regression adjusted for gender, age, cigarette smoking and alcohol consumption.