Figure 5

Downregulation of glutathione metabolism in melanoma cells. The central panel displays a partial KEGG image of the glutathione metabolism pathway. In each active 'gene box' (green), two solid squares are added to the upper left corner to reflect the associated information for the Melan-a2 melanocyte library (SMN001_36623nr2, left) and the B16F1 melanoma library (SMT001_32267nr2, right). PET counts associated with each gene isoform can be accessed by clicking on the library squares. Gene isoform-associated PET counts of the melanocyte library and the melanoma library are displayed side by side and compared to demonstrate the transcriptional downregulation of these gene isoforms in melanoma cells. PET counts are normalized to cpm (counts per million).