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Table 3 Indication for immunhistochemical (IHC) staining

From: Reliability and validity of needle biopsy evaluation of breast-abnormalities using the B-categorization – design and objectives of the Diagnosis Optimisation Study (DIOS)

Differential diagnosis IHC
Ductal hyperplasia (DH) vs. atypical epitelproliferation of ductal type (AEDT), ductal carcinoma in situ (DCIS) Cytokeratin (CK) 14, CK 8/18
DCIS vs. invasive carcinoma CK 14, smooth muscle actin (SMA), CK 8/18
Sclerosing lesions vs. invasive carcinoma CK 14, SMA
Myoepitheliale lesions CK 14, SMA