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Table 3 Indication for immunhistochemical (IHC) staining

From: Reliability and validity of needle biopsy evaluation of breast-abnormalities using the B-categorization – design and objectives of the Diagnosis Optimisation Study (DIOS)

Differential diagnosis

IHC

Ductal hyperplasia (DH) vs. atypical epitelproliferation of ductal type (AEDT), ductal carcinoma in situ (DCIS)

Cytokeratin (CK) 14, CK 8/18

DCIS vs. invasive carcinoma

CK 14, smooth muscle actin (SMA), CK 8/18

Sclerosing lesions vs. invasive carcinoma

CK 14, SMA

Myoepitheliale lesions

CK 14, SMA