Table 1 Recurrent amplicons in breast tumors with examples of some candidate oncogenes
From: Breast tumor copy number aberration phenotypes and genomic instability
Tumors | Chr. | Proximal flanking clone | Start (bp) | Distal flanking clone | End (bp) | Size (Mb) | Candidate Genes |
|---|---|---|---|---|---|---|---|
S0257; S1508 | 1 | RP11-235B24 | 50120611 | CTD-2010C4 | 64641284 | 14.5 | JUN |
S0021; S0065; S0127; S0132; S1534; S1539 | 8 | RP11-210F15 | 36452678 | RP11-262I23 | 39744917 | 3.3 | BAG1; FGFR1; TACC1 |
S0013; S0257; S1598 | 8 | RP11-128G18 | 127638988 | RP11-227F7 | 131013284 | 3.4 | MYC; WISP1 |
S0132; S0394; S1524 | 11 | CTD-2115C17 | 32421376 | RP11-18B9 | 40252688 | 7.8 | TRAF6 |
S0050; S0065; S0081; S0132; S0252; S0303; S1534; S1539; S1598 | 11 | CTD-2080I19 | 68483419 | RP11-98G24 | 76964746 | 8.5 | CCND1; FGF4; EMS1; PAK1 |
S0184; S1508 | 12 | 12pter | 0 | RP11-272L6 | 5221281 | 5.2 | CCND2; FGF6; DYRK4 |
S0051; S0052; S0122; S1522 | 12 | RP11-18B8 | 63882712 | RP11-92P22 | 74052886 | 10.2 | MDM2; DYRK2; YEATS4; HELB; |
S0021; S0043; S0052; S0059; S0257; S0394; S1511; S1522; S1526; S1539 | 17 | RP11-58O8 | 34147697 | RP11-87N6 | 38680670 | 4.5 | STARD3; ERBB2; GRB7; TOP2A; MMP28 |
S0043; S0104; S0394 | 17 | RP11-110H20 | 47546526 | RP11-481C4 | 49705574 | 2.2 | IMP-1; ITGA3 |
S0001; S0021; S0043; S0104; S1508; S1511 | 17 | RP5-1073F15 | 58499308 | CTB-244K7 | 64939230 | 6.4 | BRIP1; GH1; GH2; MAP3K3 |
S0127; S0257; S0269 | 18 | RP11-7E5 | 10817140 | RP11-10G8 | 17272427 | 6.5 | PTPN2 |
S0021; S0043; S0050; S0051; S0055; S0059; S0122; S1522; S1545; S1598 | 20 | RP11-169A6 | 44424925 | RMC20P179 | 62702798 | 18.3 | CYP24; ZNF217; STK6 |