Graph: Functional vessel density, time course. Y-axis: functional vessel density (FVD in mm/mm2), x-axis: time in days after implantation. ANOVA on ranks (p = 0.008); *p < 0.05 versus day 7, #p < 0.05 versus Control, Mann-Whitney Rank Sum Test. Significant increase in functional vessel density in both groups between days 7 and 28 after tumor implantation. Functional vessel density is significantly reduced in animals treated with Celecoxib compared to Controls on day 28. A, B: Photographs from intravital fluorescence microscopy, top-view, scale bar 200 μm. Tumor borders marked by arrows. Day 28: Celecoxib (A), Control (B).