3-Phosphoinositide-dependent Protein Kinase-1 (PDK1) promotes invasion and activation of matrix metalloproteinases

Table 1 PDK1-induced gene expression by qrt-PCR

Cell line	WDNM1	TIMP3	Lck	Collagen VI
Comma/vector	144.9 ± 11.0	156.5 ± 6.0	0.005 ± 0.001	0.56 ± 0.02
Comma/PDK1	3.1 ± 0.1	84.6 ± 2.3	43.6 ± 1.3	4.4 ± 0.3
-fold change	-46.7	-1.8	8,720	7.9
-fold change in microarray	-26.1	-2.4	41.1	10.0

Values are expressed as the absolute mRNA levels present in Comma/PDK1 and Comma/vector cells in arbitrary units relative to the expression of β-actin. Each result is the mean ± S.E. of 3 determinations. The relative values from gene microarray analysis are shown for comparison

ISSN: 1471-2407