Skip to main content

Table 4 Modulation of caspase-3/7 activity by drugs and CD40L

From: CD40L induces multidrug resistance to apoptosis in breast carcinoma and lymphoma cells through caspase independent and dependent pathways

Culture conditions Caspase-3/7 Activity (pmol/min)
Drug L cells CD40L Daudi Raji BJAB BL36 BL70 T47 D BT20
- - 14 10 3.2 15.5 10.3 1.4 2.1
ETO - 45.7 40.8 45.9 35.4 25 2 5.5
ETO + 17.5 a 15.5a 13.4a 19.4a 10a 5.3 10.2
CDDP - 21 34.6 88.6 19.1 19.5 0.9 2.2
CDDP + 23 31.2 13.9a 32.6 24.5 4 1.5
DOX - 34.8 36 10.8 37.9 23.5 3.2 8.5
DOX + 12.3a 8.2a 1.2a 18.8a 5.1a 5.2 11.3
VIN - 16.7 31.7 42.6 11.9 19 1.7 4.3
VIN + 13.8 12.7a 6.5a 14.8 7.2a 4.8 10.1
TAX - 29.7 30.6 39.2 21.2 20.4 2.3 5.4
TAX + 13.1a 9.5a 8.5a 13a 4.5a 5.7 9.8
  1. a: P < 0.05 (student's paired t-test) as compared to cells cultured with drug alone