Skip to main content

Table 4 Modulation of caspase-3/7 activity by drugs and CD40L

From: CD40L induces multidrug resistance to apoptosis in breast carcinoma and lymphoma cells through caspase independent and dependent pathways

Culture conditions

Caspase-3/7 Activity (pmol/min)

Drug

L cells CD40L

Daudi

Raji

BJAB

BL36

BL70

T47 D

BT20

-

-

14

10

3.2

15.5

10.3

1.4

2.1

ETO

-

45.7

40.8

45.9

35.4

25

2

5.5

ETO

+

17.5 a

15.5a

13.4a

19.4a

10a

5.3

10.2

CDDP

-

21

34.6

88.6

19.1

19.5

0.9

2.2

CDDP

+

23

31.2

13.9a

32.6

24.5

4

1.5

DOX

-

34.8

36

10.8

37.9

23.5

3.2

8.5

DOX

+

12.3a

8.2a

1.2a

18.8a

5.1a

5.2

11.3

VIN

-

16.7

31.7

42.6

11.9

19

1.7

4.3

VIN

+

13.8

12.7a

6.5a

14.8

7.2a

4.8

10.1

TAX

-

29.7

30.6

39.2

21.2

20.4

2.3

5.4

TAX

+

13.1a

9.5a

8.5a

13a

4.5a

5.7

9.8

  1. a: P < 0.05 (student's paired t-test) as compared to cells cultured with drug alone