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Table 2 Effect of ceramides on lymphoma and breast carcinoma cell lines apoptosis

From: CD40L induces multidrug resistance to apoptosis in breast carcinoma and lymphoma cells through caspase independent and dependent pathways

Culture conditions

% of apoptotic cell: Mean (SE)

  

LNH

breast carcinoma

Drug

L cells CD40L

Daudi

Raji

BJAB

BL36

BL70

T47 D

BT20

-

-

2 (0.3)

2 (0.3)

2 (0.3)

1 (0.2)

6 (0.5)

0 (0)

6 (0.5)

C2

-

24 (0.9)

64 (1)

13 (0.7)

64 (1)

67 (1)

29 (1)

13 (0.7)

C2

+

10 (0.7)a

17 (0.8)a

4 (0.4)a

42 (1)a

17 (0.8)a

8 (0.6)a

5 (0.5)a

C6

-

80 (0.9)

82 (0.9)

43 (1.1)

85 (0.8)

45 (1.1)

55 (1.1)

20 (0.9)

C6

+

59 (1.1)a

68 (1)a

12 (0.7)a

48 (1.1)a

20 (0.9)a

46 (1.1)

3 (0.4)a

C(-)

-

3 (0.4)

7 (0.57)

1 (0.2)

1 (0.2)

4 (0.4)

2 (0.3)

3 (0.3)

  1. a: P < 0.05 (student's paired t-test) as compared with culture with ceramide alone