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Table 1 Multidrug resistance induced by CD40L in lymphoma cell lines

From: CD40L induces multidrug resistance to apoptosis in breast carcinoma and lymphoma cells through caspase independent and dependent pathways

Culture conditions

% of apoptotic cell Mean (SE)

 

LNH

Drug

L cells CD40L

DAUDI

Raji

BJAB

BL36

BL70

-

-

2 (0.3)

2 (0.3)

2 (0.3)

1 (0.2)

6 (0.5)

ETO

-

46 (1.1)

16 (0.8)

29 (1)

45 (1.1)

23 (0.9)

ETO

+

27 (1)a

17 (0.8)

17 (0.8)a

14 (0.77)a

7 (0.6)a

CDDP

-

48 (1.1)

21 (0.9)

32 (1)

62 (1)

78 (0.9)

CDDP

+

27 (1)a

9 (0.6)a

16 (0.8)a

25 (1)a

51 (1.1)a

DOX

-

29 (1)

15 (0.8)

14 (0.8)

26 (1)

49 (1.1)

DOX

+

16 (0.8)a

8 (0.6)a

6 (0.5)a

7 (0.6)a

13 (0.7)a

VIN

-

50 (1.1)

32 (1)

28 (1)

55 (1.1)

33 (1)

VIN

+

40 (1.1)a

17 (0.8)a

7 (0.6)a

46 (1.1)a

20 (0.9)a

TAX

-

37 (1.1)

16 (0.8)

20 (0.9)

32 (1)

27 (1)

TAX

+

16 (0.8)a

21 (0.9)

8 (0.6)a

17 (0.8)a

15 (0.8)a

  1. a: P < 0.05 (student's paired t-test) as compared to cells cultured with drug alone