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Figure 4 | BMC Cancer

Figure 4

From: CD40L induces multidrug resistance to apoptosis in breast carcinoma and lymphoma cells through caspase independent and dependent pathways

Figure 4

Modulation of drug induced apoptosis by inhibitors of caspase like activities. T47 D (Panel A) and BL70 cells (Panel B) were incubated alone; or 24 hours in the presence of C2 or C6 ceramides (75 μM) or DOX (1 μg/mL); or pre-incubated 24 hours with cell permeable inhibitors of caspase-9-like activity (z-LEHD) or caspase-8-like activity (z-IETD) or caspase-3-like activity (z-DEVD) and then 24 hours with drugs (C2 or C6 or DOX). Cells were finally tested for apoptosis using the TUNEL assay as indicated in Materials and Methods. *Apoptosis was significantly decreased (Student t test, p < 0.05) upon co-culture with caspases inhibitors as compared to no caspases inhibitors.

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