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Figure 3 | BMC Cancer

Figure 3

From: Alternating current electrical stimulation enhanced chemotherapy: a novel strategy to bypass multidrug resistance in tumor cells

Figure 3

Inverse correlation between the expression of MDR1 and the intracellular uptake of doxorubicin. (a) Micro photographs showing the accumulation of doxorubicin (in red) in cells also stained for MDR1 immunoreactivity (in green). Note that electrical stimulation greatly increased the accumulation of doxorubicin in the cell nucleus while achieving a proportionate decrease of immunological reactive signal for MDR1. (b) Data summarizing the inverse relationship between MDR1 expression and doxorubicin uptake.

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